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AB SCIEX 4000 QTRAP

Quadrupole mass filters provide a robust means of sorting ions in a mass spectrometry experiment. When these mass analysers are incorporated in a triple quadrupole (QQQ) setup, which consists of three quadrupole mass filters in series, various specialised forms of quantitative and qualitative mass spectrometry can be conducted. This is achieved via the use of the first and third quadrupoles (Q1 and Q3, respectively) as mass filters, whilst the second quadrupole (Q2) is utilised as a collision cell in which precursor ions undergo collision-induced dissociation to produce fragment ions.

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Agilent 7890 GC

The Agilent 7890 is one of the high performance gas chromatographs that provide superior performance for all applications. The key to its performance is the use of advanced EPC (electronic pneumatic control) modules and high performance GC oven temperature control which allows for fast and precise temperature ramping. These specifications provide optimal chromatography including peak symmetry, repeatability of retention time and accuracy in retention time index. Agilent 7890A is expected to have retention time repeatability <0.008% or <0.0008min and area repeatability <1%RSD.

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Agilent HP 5973 MSD A & B

Gas Chromatography-mass spectrometry (GC-MS) combines two powerful analytical tools: gas chromatography for the highly efficient gas-phase separation of components in complex mixtures, and mass spectrometry for the confirmation of identity of these components as well as for the identification of unknowns. The HP 6890-5973 GC/MSD allows the analysis of small molecules (m/z 50-800) in a wide range of sample matrices. This system can be operated in electron ionisation (EI) and chemical ionisation (CI) modes.

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Agilent(HP) 1090 Micro LC and Prep LC

The HP 1090 HPLC system is useful for a wide range of applications for metabolites, peptides and proteins including: sample clean up; enrichment, and fractionation. With flow rates of between 50–5000 μl/min it suits elution using narrow bore to analytical size columns that can be detected with a UV detector. Columns can be temperature controlled and there are also 3 solvent reservoirs for solvent delivery binary, ternary or gradient elution. The application of this instrument to many kinds of separation columns is the advantage of this stand alone LC system.

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AKTA FPLC

The GE AKTA Purifier LC system and fraction collector is used predominantly for protein purification, as it has no metal parts. The system has a manual injector, with 3 channel UV and conductivity detectors. The Solvent delivery system is capable of delivering both isocratic and gradient elution, and can be used for both analytical and semi-preparative work and fractionation depending on choice of column used. Major work projects have included the purification and fractionation of cytochrome C and related products.

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Applied Biosystems QSTAR Elite

ABI QStar Elite is a high-performance, hybrid quadrupole Time-of-Flight (TOF) mass spectrometer typically used with electrospray with greater sensitivity and intelligent dependent scan functions. The system is used for protein or peptide characterisation using nano liquid chromatography and data dependent tandem mass spectrometry. The system is currently used for iTRAQ quantification of differentially expressed proteins and these normally combine online multi-dimensional liquid chromatography.

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Bruker ultrafleXtreme MALDI-TOF/TOF

Bruker ultrafleXtreme MALDI-TOF/TOF

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Desi 2-D Automated Source

(see http://www.prosolia.com/omnispray.php)

2-D Automated Models for X and Y axis movement of sample stage uses control software that:

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GE and BioRad mini and large format SDS-PAGE systems

Proteomic work can involve the use of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE or 2-DE). In 2-DE, "first dimension" electrophoresis in a polyacrylamide gel with a pH gradient and high urea concentration is followed by a "second dimension" separation in an SDS-PAGE gel. SDS-PAGE can also be used independently. Proteins and peptides are separated within the gel according to the % acrylamide and crosslinker, given as %T and %C.

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GE Healthcare iTC200 Isothermal Calorimeter

Investigating molecular interactions, reaction kinetics and thermodynamics by Isothermal Calorimeter (iTC). Production or absorption of heat is a universal event consequent to the binding of two molecules or a chemical reaction. iTC is the only equipment that can directly measure the energetics of biochemical processes involving interaction between two molecules such as a receptor and a ligand.

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GE IPGphor/Multiphor Isoelectric Focusing Systems

Isoelectric focusing (IEF) systems are used for: the fractionation of complex biological samples in pathway and systems analysis; quantitation of protein effector molecules; elucidation of protein modifications; and sample clean-up for ongoing analysis. It is used in conjunction with immobilised pH gradients of length 7cm, 13cm, or 18cm for broad range pH3-10, mid range pH4-7, 6-11, or narrow range with 0.01pH unit separating power.

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NuSep ProteomSep/MF10 Electrophoretic Partitioning Systems

This in-solution electrophoretic device is for the partitioning of μl volumes of μg-mg amounts of proteins and or peptides based on surface charge, pH, size in denaturing or native formats. It is typically used to partition contaminant proteins away from lower abundance proteins (eg. Albumin or Ig from other plasma proteins), desalting of biological samples (eg. urine, plasma, tears), enrichment of poorly concentrated and low abundance samples for further analysis. Partitioning down to 1kDa is achievable and is therefore ideal for peptide and small protein work.

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Shimadzu HPLC

The Shimadzu Prominence HPLC system is used for both analytical and semi-preparative separations. The instrument is equipped with fluorescence, photo diode array (PDA), and evaporative light scattering (ELSD) detectors, and is combined with a fraction collector. The instrument has a multitude of set-ups and combination and is capable of delivering both isocratic and gradient solvent elution from 0.2 to 10.5 mL/minute.

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Shimadzu UFLCxr

The Shimadzu XR Prominence HPLC system is used for analytical separations. The instrument has a binary pump set-up to allow both isocratic and gradient elution at high back pressures (circa 14 000 Psi), and is equipped with a photo diode array detector (PDA). A wide range of separations are performed on the instrument encompassing both normal and reverse phase conditions, with a wide variety of column chemistries utilised for identification and quantitative analysis.

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TA Instruments NanoDSC

This capillary Differential Scanning Calorimeter can be used for investigating the stability of proteins, nucleic acids, lipids and other macromolecules. Differential Scanning Calorimetry (DSC) is the only method that directly measures the stability of macromolecules in solution. The information obtained provides valuable insights into the factors (e.g. hydrophobic interactions, hydrogen bonding, conformational entropy and physical environment) that stabilize these biomolecules alone or as complexes, such as protein-ligand or micellar complexes.

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Thermo Focus DSQ

The Thermo DSQ II GC-MS instruments are our most up-to-date instruments for analysis of compounds that are sufficiently volatile to enter the gas phase intact. The Focus DSQ II GC-MS instrument at our Lower Campus mass spectrometry facility is configured as an electron impact (EI+) only system and is dedicated to analysis of gaseous environmental samples and for trace level analysis of underivatised volatile organic molecules in solution.

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Thermo LTQ FT

Thermo Scientific LTQ FT Ultra combines the most advanced Ion Trap and Fourier Transform Ion Cyclotron Resonance (ICR) technologies into a single instrument. The ICR cell design produces enhanced sensitivity and greater dynamic range. It is an ultra high resolution instrument for LC/MS with unprecedented analytical power and versatility. The instrument is provided with ESI, nano ESI and APCI ionization sources and CID and ECD fragmentation technologies.

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Thermo LTQ Orbitrap Velos

Orbitrap mass analysers are recognised for their ability to produce ultra high mass accuracy and resolution measurements; these performance capabilities allow mass spectrometry results to be interpreted with a significant degree of confidence. The Orbitrap Velos is a hybrid instrument that incorporates both Orbitrap and linear ion trap mass analysers; both 1D and 2D nano liquid chromatography (LC) separations can be interfaced to this instrument. This platform allows the benefits of Orbitrap mass analysis to be exploited in highly sensitive experiments.

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Thermo LTQ Orbitrap Velos ETD

Orbitrap mass analysers are recognised for their ability to produce ultra high mass accuracy and resolution measurements; these performance capabilities allow mass spectrometry results to be interpreted with a significant degree of confidence. The Orbitrap Velos ETD is a hybrid instrument that incorporates both Orbitrap and linear ion trap mass analysers; both 1D and 2D nano liquid chromatography (LC) separations can be interfaced to this instrument. This platform allows the benefits of Orbitrap mass analysis to be exploited in highly sensitive experiments.

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Thermo LTQ Orbitrap XL

The Orbitrap Velos XL is based at lower campus and is used for non-biological samples. Orbitrap mass analysers are recognised for their ability to produce ultra high mass accuracy and resolution measurements; these performance capabilities allow mass spectrometry results to be interpreted with a significant degree of confidence. The Thermo Scientific LTQ Orbitrap XL is a hybrid FTMS (Fourier Transform Mass Spectrometer) that incorporates the sensitive LTQ linear ion trap and Orbitrap mass analysers.

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Thermo MAT 253 IRMS with KIEL

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Thermo Orbitrap Fusion Lumos

Thermo Orbitrap Fusion Lumos

The Orbitrap Fusion Lumos includes an exclusive Tribrid design incorporating 3 different mass analysers (a quadrupole, an ion trap and an Orbitrap) enabling a large number of different experiments to be performed with a single mass spectrometer.  Software developments have also simplified the set-up of complex experiments.  Other significant technological advances including a brighter ion source and improved vacuum/pumping.  Additional enhancements of the Lumos include: greater scan speed, high mass resolving power, sensitivity and an improved ETD capability and EThcD fragm

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Thermo QExactive Plus

QExactive mass analysers are recognised for their ability to produce ultra high mass accuracy and resolution measurements in both MS and MS/MS experiments; these performance capabilities allow mass spectrometry results to be interpreted with a significant degree of confidence. The QE+ is a hybrid instrument that incorporates both quadrupole and Orbitrap mass analysers; both 1D and 2D nano liquid chromatography (LC) separations can be interfaced to this instrument.

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