A/Prof. George Smythe

Visiting Fellow

Category: Academic Staff

Biography

Current Appointments

A/Prof. (Conjoin) Faculty of Medicine, UNSW Australia
Research Advisory Committee, Autralasian Research Institute
Visiting Fellow, Bioanalytical Mass Spectrometry Facility, UNSW Australia

Role & Interests

My main research interests include the roles of neurotransmitters, tryptophan metabolism and pro-inflammatory mediators in CNS disease and brain ageing. This research has depended largely on the development of unique mass spectrometric methods for characterisation and analysis of the molecules under investigation.

Publications

Book Chapters

Poljak A;Sachdev PS;Smythe GA, 2006, 'Inflammatory, Oxidative and Vascular Factors affecting neuronal cell death in Alzheimer's Disease', in Welsh EM (ed.), Frontiers in Alzheimer`s Disease Research, edn. First, Nova Science Publications, New York, USA, pp. 1 - 54
Smythe GA;Poljak A;Bustamante S;Braga O;Maxwell A;Grant R;Sachdev P, 2003, 'ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue', in Advances in Experimental Medicine and Biology, pp. 705 - 712
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Smythe GA, 2003, 'Neuroendocrine aspects of brain ageing', in Sachdev P (ed.), The Ageing Brain, edn. 1, Swets & Zeitlinger, Lisse, Netherlands, pp. 139 - 152
Smythe GA;Matanovic G, 2002, 'Specific analysis of nitrate and nitrite by gas chromatography/mass spectrometry', in Methods in Enzymology, pp. 148 - 157, http://dx.doi.org/10.1016/S0076-6879(02)59179-5

Conference Abstracts

2009, 'Abstracts of the 42nd National Conference of the Australian Association of Gerontology. November 25-27, 2009. Canberra, ACT, Australia.', in Australas J Ageing, Australia, Vol. 28 Suppl 2, pp. A41 - 120, Australia, http://dx.doi.org/10.1111/j.1741-6612.2009.00397.x

Conference Papers

Guillemin GJ;Cullen KM;Smythe GA;Lim CK;Garner B;Brew BJ, 2008, 'Characterization of the kynurenine pathway in human primary neurons', in Proceedings of Aust Neuroscience Society, Australian Neuroscience Society 28th Annual Meeting, Hobart, pp. 78 - 78, presented at Australian Neuroscience Society 28th Annual Meeting, Hobart, 27 - 30 January 2008
Majid A;Smythe GA;Denny WA;Walkelin L, 2008, 'Interaction of chlorambucil and intercalating aniline mustards with defined DNA sequences using MALDI and ESI mass spectrometry', in EJC Supplements, Pergamon-Elsevier Science Ltd, Lyon, FRANCE, pp. 46 - 46, presented at 20th Meeting of the European Association for Cancer Research, Lyon, FRANCE, 05 - 08 July 2008
Feitz AJ;Braga O;Smythe GA;Schafer AI, 2005, 'Steroid estrogens in moving sediments at proximity to a sewage ocean outfall', in International Conference Integrated Concept in Water Recycling, International Conference Integrated Concept in Water Recycling, Wollongong, NSW, presented at International Conference Integrated Concept in Water Recycling, Wollongong, NSW, 13 - 17 February 2005
Vishnumohan S;Pickford R;Smythe GA;Arcot J, 2005, 'A sensitive and selective method for quantification of natural folates in foods using electrospray tandem MS', in Proceedings of the Nutrition Society of Australia, National Society of Australia (NSA), Melbourne, presented at Nutrition Society of Australia (2005), Melbourne, 30 November - 03 December 2005
Braga O;Smythe GA;Schafer AI;Feitz AJ, 2004, 'Steroid Estrogens in Primary and Tertiary Wastewater Treatment Plants', in 4th International Water Association World Water Congress, 4th International Water Association World Water Congress, Morocco, presented at 4th International Water Association World Water Congress, Morocco, 19 - 24 September 2004
Braga O;Schafer AI;Smythe GA, 2001, 'Analysis of endocrine disrupters & pharmaceuticals in the environment', in Schafer A;Sherman P;Waite TD (eds.), Recent Advances in Water Recycling Technologies Workshop, Recent Advances in Water Recycling Technologies Workshop, Brisbane, Qld, pp. 81 - 92, presented at Recent Advances in Water Recycling Technologies Workshop, Brisbane, Qld, 26 November 2001
Duncan MW;Smythe GA, 2000, 'Characterization of oxidatively damaged proteins and peptides by maldi-psd mass spectrometry', in Journal of Biomolecular Techniques, Journal of Biomolecular Techniques, presented at Journal of Biomolecular Techniques, 01 - 01 January 2000

Conference Proceedings (Editor of)

Poljak A;Sachdev PS;Brodaty H;Slavin MJ;Kochan NA;Trollor JN;Ng LL;Smythe GA, (eds.), 2008, 'Alzheimer's and Dementia', Elsevier, Chicago, USA, presented at Alzheimer's Association International Conference on Alzheimer's Disease, Chicago, USA, 23 - 31 July 2008

Journal articles

Jayasena T;Poljak A;Braidy N;Zhong L;Rowlands B;Muenchhoff J;Grant R;Smythe G;Teo C;Raftery M;Sachdev P, 2016, 'Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep35391
Poljak A;Crawford JD;Smythe GA;Brodaty H;Slavin MJ;Kochan NA;Trollor JN;Wen W;Mather KA;Assareh AA;Ng PC;Sachdev PS, 2016, 'The relationship between plasma aβ levels, cognitive function and brain volumetrics: Sydney memory and ageing study', Current Alzheimer Research, vol. 13, pp. 243 - 255, http://dx.doi.org/10.2174/1567205013666151218150202
Braidy N;Poljak A;Grant R;Jayasena T;Mansour H;Chan-Ling T;Smythe G;Sachdev P;Guillemin GJ, 2015, 'Differential expression of sirtuins in the aging rat brain', Frontiers in Cellular Neuroscience, vol. 9, http://dx.doi.org/10.3389/fncel.2015.00167
Jayasena T;Poljak A;Braidy N;Smythe G;Raftery M;Hill M;Brodaty H;Trollor J;Kochan N;Sachdev P, 2015, 'Upregulation of glycolytic enzymes, mitochondrial dysfunction and increased cytotoxicity in glial cells treated with Alzheimer's disease plasma', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0116092
Braidy N;Poljak A;Grant R;Jayasena T;Mansour H;Chan-Ling T;Guillemin GJ;Smythe G;Sachdev P, 2014, 'Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence', Biogerontology, vol. 15, pp. 177 - 198, http://dx.doi.org/10.1007/s10522-013-9489-5
Muenchhoff J;Poljak A;Song F;Raftery M;Brodaty H;Duncan M;McEvoy M;Attia J;Schofield PW;Sachdev PS, 2014, 'Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts', Journal of Alzheimer's Disease, vol. 43, pp. 1355 - 1373, http://dx.doi.org/10.3233/JAD-141266
Song F;Poljak A;Kochan NA;Raftery M;Brodaty H;Smythe GA;Sachdev PS, 2014, 'Plasma protein profiling of Mild Cognitive Impairment and Alzheimer's disease using iTRAQ quantitative proteomics', Proteome Science, vol. 12, http://dx.doi.org/10.1186/1477-5956-12-5
Jayasena T;Poljak A;Smythe G;Braidy N;Münch G;Sachdev P, 2013, 'The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease', Ageing Research Reviews, vol. 12, pp. 867 - 883, http://dx.doi.org/10.1016/j.arr.2013.06.003
Blumenthal A;Nagalingam G;Huch JH;Walker L;Guillemin GJ;Smythe GA;Ehrt S;Britton WJ;Saunders BM, 2012, 'M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0037314
Song F;Poljak A;Crawford J;Kochan NA;Wen W;Cameron B;Lux O;Brodaty H;Mather K;Smythe GA;Sachdev PS, 2012, 'Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0034078
Song F;Poljak A;Valenzuela M;Mayeux R;Smythe GA;Sachdev PS, 2011, 'Meta-analysis of plasma amyloid-β levels in Alzheimer's disease.', Journal of Alzheimer's disease : JAD, vol. 26, pp. 365 - 375, http://dx.doi.org/10.3233/JAD-2011-101977
Grant RS;Coggan SE;Smythe GA, 2009, 'The physiological action of picolinic acid in the human brain', International Journal of Tryptophan Research, vol. 2, pp. 71 - 79
Song F;Poljak A;Smythe GA;Sachdev P, 2009, 'Plasma biomarkers for mild cognitive impairment and Alzheimer's disease', Brain Research Reviews, vol. 61, pp. 69 - 80, http://dx.doi.org/10.1016/j.brainresrev.2009.05.003
Coggan SE;Smythe GA;Bilgin A;Grant RS, 2009, 'Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid', Journal of Neurochemistry, vol. 108, pp. 1220 - 1225, http://dx.doi.org/10.1111/j.1471-4159.2009.05868.x
Abdul Majid AM S;Smythe G;Denny WA;Wakelin LP G, 2009, 'Mass spectrometry studies of the binding of the minor groove-directed alkylating agent alkamin to AT-Tract oligonucleotides', Chemical Research in Toxicology, vol. 22, pp. 146 - 157, http://dx.doi.org/10.1021/tx800276h
Hutton LC;Castillo-Melendez M;Smythe GA;Walker DW, 2008, 'Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation', American Journal of Obstetrics and Gynecology, vol. 198, pp. 117.e1 - 117.e11, http://dx.doi.org/10.1016/j.ajog.2007.06.035
Owe-Young R;Webster NL;Mukhtar M;Pomerantz RJ;Smythe G;Walker D;Armati PJ;Crowe SM;Brew BJ, 2008, 'Kynurenine pathway metabolism in human blood-brain-barrier cells: Implications for immune tolerance & neurotoxicity', Journal of Neurochemistry, vol. 105, pp. 1346 - 1357, http://dx.doi.org/10.1111/j.1471-4159.2008.05241.x
Abdul Majid AM S;Smythe G;Denny WA;Wakelin LP G, 2007, 'Erratum: Structure of the d(CGCGAATTCGCG)2 complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry (Molecular Pharmacology (2007) 71 (1165-1178))', Molecular Pharmacology, vol. 72, pp. 485, http://dx.doi.org/10.1124/mol.72.2.485
Sainsbury A;Lin S;McNamara K;Slack K;Enriquez R;Lee NJ;Boey D;Smythe GA;Schwarzer C;Baldock P;Karl T;Lin EJ D;Couzens M;Herzog H, 2007, 'Dynorphin Knockout Reduces Fat Mass and Increases Weight Loss during Fasting in Mice', Molecular Endocrinology, vol. 21, pp. 1722 - 1735, http://dx.doi.org/10.1210/me.2006-0367
Guillemin GJ;Brew BJ;Noonan CE;Knight TG;Smythe GA;Cullen KM, 2007, 'Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques', International Congress Series, vol. 1304, pp. 404 - 408, http://dx.doi.org/10.1016/j.ics.2007.07.012
Majid AM S A;Smythe G;Denny WA;Wakelin LP G, 2007, 'Structure of the d(CGCGAATTCGCG)2 complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry', Molecular Pharmacology, vol. 71, pp. 1165 - 1178, http://dx.doi.org/10.1124/mol.106.030072
Guelfi KJ;Ratnam N;Smythe GA;Jones TW;Fournier PA, 2007, 'Effect of intermittent high-intensity compared with continuous moderate exercise on glucose production and utilization in individuals with type 1 diabetes', American Journal of Physiology - Endocrinology and Metabolism, vol. 292, http://dx.doi.org/10.1152/ajpendo.00533.2006
Matayatsuk C;Poljak A;Bustamante S;Smythe GA;Kalpravidh RW;Sirankapracha P;Fucharoen S;Wilairat P, 2007, 'Quantitative determination of ortho- and meta-tyrosine as biomarkers of protein oxidative damage in β-thalassemia', Redox Report, vol. 12, pp. 219 - 228, http://dx.doi.org/10.1179/135100007X200272
Jayasena T;Grant RS;Keerthisinghe N;Solaja I;Smythe GA, 2007, 'Membrane permeability of redox active metal chelators: An important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells', Neuroscience Research, vol. 57, pp. 454 - 461, http://dx.doi.org/10.1016/j.neures.2006.12.004
Lim CK;Smythe GA;Stocker R;Brew BJ;Guillemin GJ, 2007, 'Characterization of the kynurenine pathway in human oligodendrocytes', International Congress Series, vol. 1304, pp. 213 - 217, http://dx.doi.org/10.1016/j.ics.2007.07.011
Guillemin GJ;Cullen KM;Lim CK;Smythe GA;Garner B;Kapoor V;Takikawa O;Brew BJ, 2007, 'Characterization of the kynurenine pathway in human neurons', Journal of Neuroscience, vol. 27, pp. 12884 - 12892, http://dx.doi.org/10.1523/JNEUROSCI.4101-07.2007
Guillemin GJ;Cullen K;Smythe GA;Kapoor V;Lim E;Garner B;Takikawa O;Brew BJ, 2007, 'Characterization of the kynurenine pathway in human neurons', Journal of the History of the Neurosciences, vol. 27, pp. 12884 - 12892
Xia W;Wang Y;Appleyard RC;Smythe GA;Murrell GA C, 2006, 'Spontaneous recovery of injured Achilles tendon in inducible nitric oxide synthase gene knockout mice', Inflammation Research, vol. 55, pp. 40 - 45, http://dx.doi.org/10.1007/s00011-005-0006-4
Poljak A;Grant R;Austin CJ D;Jamie JF;Willows RD;Takikawa O;Littlejohn TK;Truscott RJ W;Walker MJ;Sachdev P;Smythe GA, 2006, 'Inhibition of indoleamine 2,3 dioxygenase activity by H2O2', Archives of Biochemistry and Biophysics, vol. 450, pp. 9 - 19, http://dx.doi.org/10.1016/j.abb.2006.03.003
Poljak A;Sachdev P;Smythe GA, 2006, 'Causes and diagnosis of Alzheimer's disease: A proteomics approach', Current Proteomics, vol. 3, pp. 81 - 112, http://dx.doi.org/10.2174/157016406778194635
Hutton L;Castillo-Melendez M;Smythe GA;Scheerlinck J;Walker DW, 2006, 'Utero-placental inflammation results in increased fetal systemic concentrations of the neurotoxin quinolinic acid and apoptosis in the fetal brain', Journal of the Society for Gynecologic Investigation, vol. 13, pp. 304A - 304A
Braga O;Smythe GA;Schäfer AI;Feitz AJ, 2005, 'Erratum: Fate of steroid estrogens in Australian inland and coastal wastewater treatment plants (Environmental Science and Technology (2005) 39 (3351-3358))', Environmental Science and Technology, vol. 39, pp. 7344, http://dx.doi.org/10.1021/es0514242
Manuelpillai U;Ligam P;Smythe G;Wallace EM;Hirst J;Walker DW, 2005, 'Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection', American Journal of Obstetrics and Gynecology, vol. 192, pp. 280 - 288, http://dx.doi.org/10.1016/j.ajog.2004.06.090
Yan E;Castillo-Meléndez M;Smythe G;Walker D, 2005, 'Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain', Neuroscience, vol. 134, pp. 867 - 875, http://dx.doi.org/10.1016/j.neuroscience.2005.04.056
Braga O;Smythe GA;Schäfer AI;Feitz AJ, 2005, 'Fate of steroid estrogens in Australian inland and coastal wastewater treatment plants', Environmental Science and Technology, vol. 39, pp. 3351 - 3358, http://dx.doi.org/10.1021/es0501767
Clark CJ;Mackay GM;Smythe GA;Bustamante S;Stone TW;Phillips RS, 2005, 'Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition', Infection and Immunity, vol. 73, pp. 5249 - 5251, http://dx.doi.org/10.1128/IAI.73.8.5249-5251.2005
Braga O;Smythe GA;Schäfer AI;Feitz AJ, 2005, 'Steroid estrogens in ocean sediments', Chemosphere, vol. 61, pp. 827 - 833, http://dx.doi.org/10.1016/j.chemosphere.2005.04.053
Braga O;Smythe GA;Schafer AI;Feitz AJ, 2005, 'Steroid estrogens in primary and tertiary wastewater treatment plants', Water Science and Technology, vol. 52, pp. 273 - 278
Guillemin GJ;Smythe G;Takikawa O;Brew BJ, 2005, 'Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons', GLIA, vol. 49, pp. 15 - 23, http://dx.doi.org/10.1002/glia.20090
Guillemin GJ;Smythe GA;Takikawa O;Brew BJ, 2005, 'Expression of indoleamine 2,3 dioxygenase and production of quinolinic acid by human microglia, astrocytes and neurons', Glia, vol. 49, pp. 15 - 23
Poljak A;McLean CA;Sachdev P;Brodaty H;Smythe GA, 2004, 'Quantification of Hemorphins in Alzheimer's Disease Brains', Journal of Neuroscience Research, vol. 75, pp. 704 - 714, http://dx.doi.org/10.1002/jnr.20020
De Ambrosis AE;Arcot J;Haber P;Paterson JL;Smythe GA;Guilhaus M, 2004, 'Bioavailability of folic acid from fortified rice in humans using stable isotope techniques', Asia Pacific Journal of Clinical Nutrition, vol. 13, pp. 57 - 57
Guillemin GJ;Smythe GA;Veas LA;Takikawa O;Brew BJ, 2003, 'A1-42 induces production of quinolinic acid by human macrophages and microglia', NeuroReport, vol. 14, pp. 165 - 181
Guillemin GJ;Smith DG;Smythe GA;Armati PJ;Brew BJ, 2003, 'Expression of the kynurenine pathway enzymes in human microglia and macrophages', Advances in Experimental Medicine and Biology, vol. 527, pp. 105 - 112
Guillemin GJ;Williams KR;Smith DG;Smythe GA;Croitoru-Lamoury J;Brew BJ, 2003, 'Quinolinic acid in the pathogenesis of alzheimer's disease', Advances in Experimental Medicine and Biology, vol. 527, pp. 167 - 176
Wang X;Smythe GA, 2003, 'Assessment of hydroxyl radical generation and radical scavenging activity of Chinese-medicinal herbs using GC-MS', Redox Report, vol. 8, pp. 223 - 228, http://dx.doi.org/10.1179/135100003225002727
Wang X;Kapoor V;Smythe GA, 2003, 'Extraction and chromatography-mass spectrometric analysis of the active principles from selected Chinese herbs and other medicinal plants', American Journal of Chinese Medicine, vol. 31, pp. 927 - 944, http://dx.doi.org/10.1142/S0192415X0300165X
Guillemin GJ;Smythe GA;Veas LA;Takikawa O;Brew BJ, 2003, 'A beta 1-42 induces production of quinolinic acid by human macrophages and microglia.', Neuroreport, vol. 14, pp. 2311 - 2315, http://dx.doi.org/10.1097/00001756-200312190-00005
Poljak A;Dawes IW;Ingelse BA;Duncan MW;Smythe GA;Grant CM, 2003, 'Oxidative damage to proteins in yeast cells exposed to adaptive levels of H2O2', Redox Report, vol. 8, pp. 371 - 377, http://dx.doi.org/10.1179/135100003225003401
Medana IM;Day NP J;Salahifar-Sabet H;Stocker R;Smythe G;Bwanaisa L;Njobvu A;Kayira K;Turner GD H;Taylor TE;Hunt NH, 2003, 'Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria', Journal of Infectious Diseases, vol. 188, pp. 844 - 849, http://dx.doi.org/10.1086/377583
Guillemin GJ;Smythe GA;Veas LA;Takikawa O;Brew BJ, 2003, 'A beta I-42 induces production of quinolinic acid by human macrophagesand microglia', Neuroreport, vol. 14, pp. 2311 - 2315
Guillemin GJ;Williams K;Smith DG;Smythe GA;Croitoru-Lamoury J;Brew BJ, 2003, 'Quinolinic acid in the pathogenesis of Alzheimer`s disease', Advances in Experimental Medicine and Biology, vol. 527, pp. 167 - 176, http://www.springer.com/series/5584
Medana IM;Tran TH;Day NP;Nguyen HP;Mai NT H;Ly VC O;Chau TT H;Taylor A;Salahifar H;Stocker R;Smythe G;Turner GD H;Farrar J;White NJ;Hunt NH, 2002, 'The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria', Journal of Infectious Diseases, vol. 185, pp. 650 - 656, http://dx.doi.org/10.1086/339009
Smythe GA;Braga O;Brew BJ;Grant RS;Guillemin GJ;Kerr SJ;Walker DW, 2002, 'Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography - Mass spectrometry', Analytical Biochemistry, vol. 301, pp. 21 - 26, http://dx.doi.org/10.1006/abio.2001.5490
Guillemin GJ;Kerr SJ;Pemberton LA;Smith DG;Smythe GA;Armati PJ;Brew BJ, 2001, 'IFN-β 1binduces kynurenine pathway metabolism in human macrophages: Potential implications for multiple sclerosis treatment', Journal of Interferon and Cytokine Research, vol. 21, pp. 1097 - 1101, http://dx.doi.org/10.1089/107999001317205231
Nicholls T;Lacey B;Nitsos I;Smythe G;Walker DW, 2001, 'Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency', American Journal of Obstetrics and Gynecology, vol. 184, pp. 203 - 208, http://dx.doi.org/10.1067/mob.2001.108862
Nicholls T;Nitsos I;Smythe G;Walker DW, 2001, 'Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas', American Journal of Obstetrics and Gynecology, vol. 185, pp. 988 - 995, http://dx.doi.org/10.1067/mob.2001.117969
Smith DG;Guillemin GJ;Pemberton L;Kerr S;Nath A;Smythe GA;Brew BJ, 2001, 'Quinolinic acid is produced by macrophages stimulated platelet activating factor, Nef and Tat', Journal of NeuroVirology, vol. 7, pp. 56 - 60, http://dx.doi.org/10.1080/135502801300069692
Gotoh M;Iguchi A;Kakumu S;Hirooka Y;Smythe GA, 2001, 'Central suppressive effect of octreotide on the hyperglycemic response to 2-deoxy-D-glucose injection or cold-swim stress in awake rats: Possible mediation role of hypothalamic noradrenergic drive', Brain Research, vol. 895, pp. 146 - 152, http://dx.doi.org/10.1016/S0006-8993(01)02063-7
Davies SM K;Poljak A;Duncan MW;Smythe GA;Murphy MP, 2001, 'Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats', Free Radical Biology and Medicine, vol. 31, pp. 181 - 190, http://dx.doi.org/10.1016/S0891-5849(01)00576-7
Gotoh M;Takagi J;Mori S;Yatoh M;Hirooka Y;Yamanouchi K;Smythe GA, 2001, 'Octreotide-induced suppression of the hyperglycemic response to neostigmine or bombesin: Relationship to hypothalamic noradrenergic drive', Brain Research, vol. 919, pp. 155 - 159, http://dx.doi.org/10.1016/S0006-8993(01)03018-9
Guillemin GJ;Kerr SJ;Smythe GA;Smith DG;Kapoor V;Armati PJ;Croitoru J;Brew BJ, 2001, 'Kynurenine pathway metabolism in human astrocytes: A paradox for neuronal protection', Journal of Neurochemistry, vol. 78, pp. 842 - 853, http://dx.doi.org/10.1046/j.1471-4159.2001.00498.x
Guillemin GJ;Smith DG;Kerr SJ;Smythe GA;Kapoor V;Armati PJ;Brew BJ, 2000, 'Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis', Redox Report, vol. 5, pp. 108 - 111, http://dx.doi.org/10.1179/135100000101535375
Guillemin GJ;Kerr SJ;Smythe GA;Armati PJ;Brew BJ, 2000, 'Kynurenine pathway metabolism in human astrocytes', Advances in Experimental Medicine and Biology, vol. 467, pp. 125 - 131
Yi D;Ingelse BA;Duncan MW;Smythe GA, 2000, 'Quantification of 3-nitrotyrosine in biological tissues and fluids: Generating valid results by eliminating artifactual formation', Journal of the American Society for Mass Spectrometry, vol. 11, pp. 578 - 586, http://dx.doi.org/10.1016/S1044-0305(00)00113-6
Guillemin GJ;Smith DD;Kerr SJ;Smythe GA;Kapoor V;Armati P;Brew BJ, 2000, 'Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neutopathogenesis', Redox Report, pp. 108 - 111
Smythe GA;Matanovic G;Yi D;Duncan MW, 1999, 'Trifluoroacetic anhydride-catalyzed nitration of toluene as an approach to the specific analysis of nitrate by gas chromatography-mass spectrometry', Nitric Oxide - Biology and Chemistry, vol. 3, pp. 67 - 74, http://dx.doi.org/10.1006/niox.1999.0210
Grant RS;Passey R;Matanovic G;Smythe G;Kapoor V, 1999, 'Evidence for increased de Novo synthesis of NAD in immune-activated RAW264.7 Macrophages: A self-protective mechanism?', Archives of Biochemistry and Biophysics, vol. 372, pp. 1 - 7, http://dx.doi.org/10.1006/abbi.1999.1381
Smythe GA;Duncan MW, 1997, 'Immunoassay of catecholamines and metabolites.', Clinical chemistry, vol. 43, pp. 2011 - 2012
Kerr SJ;Armati PJ;Pemberton LA;Smythe G;Tattam B;Brew BJ, 1997, 'Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages', Neurology, vol. 49, pp. 1671 - 1681, http://dx.doi.org/10.1212/WNL.49.6.1671
Smythe GA;Drew CM, 1997, 'REPCAT: Desktop expert system for interpreting and validating laboratory data for pheochromocytoma diagnosis with the database application omnis 7(TM)', Clinical Chemistry, vol. 43, pp. 134 - 140
Yi D;Smythe GA;Blount BC;Duncan MW, 1997, 'Peroxynitrite-mediated nitration of peptides: Characterization of the products by electrospray and combined gas chromatography-mass spectrometry', Archives of Biochemistry and Biophysics, vol. 344, pp. 253 - 259, http://dx.doi.org/10.1006/abbi.1997.0218
Pemberton LA;Kerr SJ;Smythe G;Brew BJ, 1997, 'Quinolinic acid production by macrophages stimulated with IFN-γ, TNF- α, and IFN-α', Journal of Interferon and Cytokine Research, vol. 17, pp. 589 - 595, http://dx.doi.org/10.1089/jir.1997.17.589
Cerpa-Poljak A;Lahnstein J;Mason KE;Smythe GA;Duncan MW, 1997, 'Mass spectrometric identification and quantification of hemorphins extracted from human adrenal and pheochromocytoma tissue', Journal of Neurochemistry, vol. 68, pp. 1712 - 1719
Pemberton LA;Kerr SJ;Smythe GA;Brew BJ, 1997, 'Quinolinic acid production by macrophages stimulate with interferon y tumour necrosis factor a and interferon a', Journal of Interferon and Cytokine Research, vol. 17, pp. 589 - 595
Smythe GA;Duncan MW, 1997, 'Immunoassay of catecholamines and metabolites', Clinical Chemistry, pp. 1
Smythe GA, 1996, 'Accuracy in clinical chemistry - a role for mass spectrometry?', Today's Life Science, pp. 33 - 36
Winlaw DS;Schyvens CG;Smythe GA;Du ZY;Rainer SP;Lord RS A;Spratt PM;Macdonald PS, 1995, 'Selective inhibition of nitric oxide production during cardiac allograft rejection causes a small increase in graft survival', Transplantation, vol. 60, pp. 77 - 82, http://dx.doi.org/10.1097/00007890-199507150-00015
Winlaw DS;Smythe GA;Keogh AM;Schyvens CG;Spratt PM;Macdonald PS, 1995, 'Nitric oxide production and heart failure', The Lancet, vol. 345, pp. 390 - 391, http://dx.doi.org/10.1016/S0140-6736(95)90379-8
Hartley LR;Arnold PK;Smythe G;Hansen J, 1994, 'Indicators of fatigue in truck drivers', Applied Ergonomics, vol. 25, pp. 143 - 156, http://dx.doi.org/10.1016/0003-6870(94)90012-4
Gotoh M;Hirooka Y;Tajima T;Iguchi A;Smythe GA, 1994, 'Adrenocorticotropin and growth hormone secretions after intracerebroventricular administration of neostigmine in rats: their relationships to hypothalamic monoaminergic neuronal activities', Brain Research, vol. 659, pp. 259 - 262, http://dx.doi.org/10.1016/0006-8993(94)90889-3
Winlaw DS;Schyvens CG;Smythe GA;Du Z;Rainer SP;Keogh AM;Mundy JA;Lord RS A;Spratt PM;Macdonald PS, 1994, 'Urinary nitrate excretion is a noninvasive indicator of acute cardiac allograft rejection and nitric oxide production in the rat', Transplantation, vol. 58, pp. 1031 - 1036, http://dx.doi.org/10.1097/00007890-199411150-00010
Winlaw DS;Keogh AM;Schyvens CG;Spratt PM;Macdonald PS;Smythe GA, 1994, 'Increased nitric oxide production in heart failure', The Lancet, vol. 344, pp. 373 - 374, http://dx.doi.org/10.1016/S0140-6736(94)91403-6
Varelis P;Smythe GA;Hodgson D;Lazarus L, 1994, 'Measurement of urinary free cortisol by stable isotope dilution mass spectrometry using a new cortisol derivative', Journal of Chromatography B: Biomedical Sciences and Applications, vol. 660, pp. 151 - 157, http://dx.doi.org/10.1016/0378-4347(94)00281-9
Graham PE;Smythe GA;Edwards GA;Lazarus L, 1993, 'Laboratory diagnosis of phaeochromocytoma: Which analytes should we measure?', Annals of Clinical Biochemistry, vol. 30, pp. 129 - 134, http://dx.doi.org/10.1177/000456329303000203
Smythe GA;Edwards G;Graham P;Lazarus L, 1992, 'Biochemical diagnosis of pheochromocytoma by simultaneous measurement of urinary excretion of epinephrine and norepinephrine', Clinical Chemistry, vol. 38, pp. 486 - 492
Edwards GA;Smythe GA;Graham PE;Lazarus L, 1992, 'The impact of recent advances in diagnostic technology on the clinical presentation of phaeochromocytoma', Medical Journal of Australia, vol. 156, pp. 153 - 157
Smythe GA;Edwards SR, 1992, 'Suppression of central noradrenergic neuronal activity inhibits hyperglycemia', American Journal of Physiology - Endocrinology and Metabolism, vol. 263
Storlien LH;Smythe GA, 1992, 'd-Fenfluramine effects on hypothalamic monoamine activities and their hormonal correlates', Brain Research, vol. 597, pp. 60 - 65, http://dx.doi.org/10.1016/0006-8993(92)91505-9
Gotoh M;Smythe GA;Iguchi A, 1992, 'Relationship between hypothalamic noradrenergic activity and the sympathetic activity in interscapular brown adipose tissue after cold-swim stress in rats', Life Sciences, vol. 51, pp. 1057 - 1063, http://dx.doi.org/10.1016/0024-3205(92)90505-J
Gotoh M;Smythe GA, 1992, 'Effects of intracerebroventricularly administered neostigmine on hypothalamic monoaminergic neuronal activities in awake rats', Brain Research, vol. 586, pp. 340 - 343, http://dx.doi.org/10.1016/0006-8993(92)91645-U
Mitchell PB;Smythe GA;Dinan TG;O'Keane V, 1992, 'Elevated cortisol concentrations and the diminished prolactin response to fenfluramine [18]', American Journal of Psychiatry, vol. 149, pp. 851 - 852
Bruce DG;Chisholm DJ;Storlien LH;Kraegen EW;Smythe GA, 1992, 'The effects of sympathetic nervous system activation and psychological stress on glucose metabolism and blood pressure in subjects with Type 2 (non-insulin-dependent) diabetes mellitus', Diabetologia, vol. 35, pp. 835 - 843, http://dx.doi.org/10.1007/BF00399929
Drummond PD;Finch PM;Smythe GA, 1991, 'Reflex sympathetic dystrophy: The significance of differing plasma catecholamine concentrations in affected and unaffected limbs', Brain, vol. 114, pp. 2025 - 2036, http://dx.doi.org/10.1093/brain/114.5.2025
Gotoh M;Smythe GA, 1991, 'Effects of intracerebroventricularly administered neostigmine on sympathetic neural activities of peripheral tissues in rats', Brain Research, vol. 548, pp. 326 - 328, http://dx.doi.org/10.1016/0006-8993(91)91142-N
Smythe GA;Edwards SR, 1991, 'A role for central postsynaptic α2-adrenoceptors in glucoregulation', Brain Research, vol. 562, pp. 225 - 229, http://dx.doi.org/10.1016/0006-8993(91)90625-6
Mitchell PB;Smythe GA, 1991, 'Endocrine and amine responses to D,L-fenfluramine in normal subjects', Psychiatry Research, vol. 39, pp. 141 - 153, http://dx.doi.org/10.1016/0165-1781(91)90083-2
Mitchell P;Smythe G;Parker G;Wilhelm K;Brodaty H;Boyce P;Hickie I, 1991, 'Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls', Psychiatry Research, vol. 37, pp. 179 - 193, http://dx.doi.org/10.1016/0165-1781(91)90074-Y
Pascoe WS;Smythe GA;Storlien LH, 1991, 'Enhanced responses to stress induced by fat-feeding in rats: relationship between hypothalamic noradrenaline and blood glucose', Brain Research, vol. 550, pp. 192 - 196, http://dx.doi.org/10.1016/0006-8993(91)91317-T
Mitchell P;Smythe G;Torda T, 1991, 'Response', Biological Psychiatry, vol. 29, pp. 619 - 620, http://dx.doi.org/10.1016/0006-3223(91)90099-8
Holmes LJ;Storlien LH;Smythe GA, 1990, 'Medial basal hypothalamic monoamine activity associated with intracerebroventricular p-chlorophenylalanine-induced hyperphagia', Brain Research, vol. 528, pp. 269 - 272, http://dx.doi.org/10.1016/0006-8993(90)91667-6
Mitchell P;Smythe G, 1990, 'Hormonal responses to fenfluramine in depressed and control subjects', Journal of Affective Disorders, vol. 19, pp. 43 - 51, http://dx.doi.org/10.1016/0165-0327(90)90008-V
Mitchell P;Smythe G;Parker G;Wilhelm K;Hickie I;Brodaty H;Boyce P, 1990, 'Hormonal responses to fenfluramine in depressive subtypes', British Journal of Psychiatry, vol. 157, pp. 551 - 557
Mitchell P;Smythe G;Torda T, 1990, 'Effect of the anesthetic agent propofol on hormonal responses to ECT', Biological Psychiatry, vol. 28, pp. 315 - 324, http://dx.doi.org/10.1016/0006-3223(90)90659-P
Smythe GA;Storlien LH, 1989, 'The role of brain noradrenaline in the neural control of glucoregulation', Diabetes 1988: proceedings of the 13th Congress of the International Diabetes Federation. ICS800
Russell J;Hooper M;Storlien L;Smythe GA, 1989, 'Insulin, glucose, and cortisol levels in bulimia: Effect of treatment', International Journal of Eating Disorders, vol. 8, pp. 635 - 646, http://dx.doi.org/10.1002/1098-108X(198911)8:6<635::AID-EAT2260080604>3.0.CO;2-P
Holmes LJ;Smythe GA;Storlien LH, 1989, 'Monoaminergic activity at the level of the hypothalamus and striatum: relationship to anticipated feeding and pancreatic insulin responses', Brain Research, vol. 496, pp. 204 - 210, http://dx.doi.org/10.1016/0006-8993(89)91067-6
Holmes LJ;Storlien LH;Smythe GA, 1989, 'Hypothalamic monoamines associated with the cephalic phase insulin response', American Journal of Physiology - Endocrinology and Metabolism, vol. 256
Pascoe WS;Smythe GA;Storlien LH, 1989, '2-Deoxy-d-glucose-induced hyperglycemia: role for direct sympathetic nervous system activation of liver glucose output', Brain Research, vol. 505, pp. 23 - 28, http://dx.doi.org/10.1016/0006-8993(89)90111-X
Thomas GB;Cummins JT;Doughton BW;Griffin N;Smythe GA;Gleeson RM;Clarke IJ, 1989, 'Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep', Journal of Endocrinology, vol. 123, pp. 393 - 402, http://dx.doi.org/10.1677/joe.0.1230393
Thomas GB;Cummins JT;Smythe GA;Gleeson RM;Dow RC;Fink G;Clarke IJ, 1989, 'Concentrations of dopamine and noradrenaline in hypophysial portal blood in the sheep and the rat', Journal of Endocrinology, vol. 121, pp. 141 - 147, http://dx.doi.org/10.1677/joe.0.1210141
Smythe GA;Pascoe WS;Storlien LH, 1989, 'Hypothalamic noradrenergic and sympathoadrenal control of glycemia after stress', American Journal of Physiology - Endocrinology and Metabolism, vol. 256
Storlien LH;Thorburn AW;Smythe GA;Jenkins AB;Chisholm DJ;Kraegen EW, 1989, 'Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats', Diabetes, vol. 38, pp. 499 - 503, http://dx.doi.org/10.2337/diab.38.4.499
Duncan MW;Compton P;Lazarus L;Smythe GA, 1988, 'Measurement of norepinephrine and 3,4-dihydroxyphenylglycol in urine and plasma for the diagnosis of pheochromocytoma', New England Journal of Medicine, vol. 319, pp. 136 - 142, http://dx.doi.org/10.1056/NEJM198807213190303
Smythe GA;Gleeson RM;Stead BM, 1988, 'Mechanisms of 5-hydroxy-l-tryptophan-induced adrenocorticotropin release: A major role for central noradrenergic drive', Neuroendocrinology, vol. 47, pp. 389 - 397, http://dx.doi.org/10.1159/000124944
Elliott WJ;Ganguly A;Duncan MW;Lazarus L;Compton P;Smythe GA, 1988, 'Diagnosis of Pheochromocytoma', New England Journal of Medicine, vol. 319, pp. 1417 - 1418, http://dx.doi.org/10.1056/NEJM198811243192115
Clezy PS;Duncan MW;Smythe GA, 1988, 'Preparation of a deuterated analogue of tetrahydropapaveroline suitable for use as an internal standard for G.C./M.S. analysis of this alkaloid: Retro pictet-spengler condensation', Australian Journal of Chemistry, vol. 41, pp. 483 - 491, http://dx.doi.org/10.1071/CH9880483
Bruce DG;Chisholm DJ;Storlien LH;Smythe GA;Kragen EW, 1988, 'Acute Psychological Stress Does Not Cause Hyperglycemia in Noninsulin Dependent Diabetes Mellitus Despite an Increased Sensitivity to Sympathomimetic Agents', The Diabetes Educator, vol. 14, pp. 229, http://dx.doi.org/10.1177/014572178801400317
Smythe GA;Gleeson RM;Stead BH, 1987, 'Stimulation of the hypothalamic–pituitary–adrenal axis and inhibition of growth hormone release via increased central noradrenaline neuronal activity by urethane anaesthesia in the rat: Blockade by cl', Australian Journal of Biological Sciences, vol. 40, pp. 91 - 96, http://dx.doi.org/10.1071/BI9870091
Mitchell PB;Smythe GA, 1987, 'Growth hormone response to clonidine in depression.', American Journal of Psychiatry, vol. 144, pp. 690 - 691
Ho KY;Smythe GA;Lazarus L, 1986, 'Normal lactotroph sensitivity to graded low-dose dopamine infusions in pathological hyperprolactinemia', Neuroendocrinology, vol. 43, pp. 175 - 181, http://dx.doi.org/10.1159/000124525
Hunt GE;O'Sullivan BT;Johnson GF S;Smythe GA, 1986, 'Growth hormone and cortisol secretion after oral clonidine in healthy adults', Psychoneuroendocrinology, vol. 11, pp. 317 - 325, http://dx.doi.org/10.1016/0306-4530(86)90017-X
Grunstein HS;Smythe GA;Bradshaw JE;Compton PJ, 1986, 'Tolbutamide increases hypothalamic serotonin activity in the rat', Diabetes, vol. 35, pp. 475 - 480, http://dx.doi.org/10.2337/diab.35.4.475
Hart RM;Keast D;Smythe G, 1986, 'Metabolic stability of Phytophthora cinnamomi Rands in Western Australia', Canadian Journal of Microbiology, vol. 32, pp. 820 - 822, http://dx.doi.org/10.1139/m86-150
Grunstein HS;Gleeson RM;Smythe GA, 1986, 'Relationship between hypothalamic noradrenergic neuronal activity and serum 3-methoxy-4-hydroxyphenylethylene glycol in the rat', Life Sciences, vol. 39, pp. 207 - 213, http://dx.doi.org/10.1016/0024-3205(86)90532-1
Ho KY;Smythe GA;Lazarus L, 1985, 'Enhanced hypothalamic dopaminergic inhibition of LH, TSH and GH release in patients with pathological hyperprolactinaemia', Acta Endocrinologica, vol. 108, pp. 289 - 296
HO KY;SMYTHE GA;LAZARUS L, 1985, 'THE INTERACTION OF TRH AND DOPAMINERGIC MECHANISMS IN THE REGULATION OF STIMULATED PROLACTIN RELEASE IN MAN', Clinical Endocrinology, vol. 23, pp. 7 - 16, http://dx.doi.org/10.1111/j.1365-2265.1985.tb00177.x
HO KY;SMYTHE GA;COMPTON PJ;LAZARUS L, 1985, 'LONG‐TERM BROMOCRIPTINE THERAPY MAY RESTORE THE INHIBITORY CONTROL OF PROLACTIN RELEASE IN SOME PATIENTS WITH PATHOLOGICAL HYPERPROLACTINEMIA', Australian and New Zealand Journal of Medicine, vol. 15, pp. 213 - 219, http://dx.doi.org/10.1111/j.1445-5994.1985.tb04009.x
Smythe GA;Bradshaw JE;Nicholson MV;Grunstein HS;Storlien LH, 1985, 'Rapid bidirectional effects of insulin on hypothalamic noradrenergic and serotoninergic neuronal activity in the rat: Role in glucose homeostasis', Endocrinology, vol. 117, pp. 1590 - 1597, http://dx.doi.org/10.1210/endo-117-4-1590
Smythe GA;Bradshaw JE;Gleeson RM;Grunstein HS;Nicholson MV, 1985, 'The central vs. peripheral effects of clonidine on ACTH, corticosterone and glucose release', European Journal of Pharmacology, vol. 111, pp. 401 - 403, http://dx.doi.org/10.1016/0014-2999(85)90651-X
Smythe GA;Bradshaw JE;Gleeson RM;Nicholson MV, 1985, 'Dopamine-β-hydroxylase inhibition acutely stimulates rats hypothalamic noradrenaline and dopamine neuronal activity as assessed from metabolic ratios and circulating glucose and ACTH responses', Life Sciences, vol. 37, pp. 841 - 847, http://dx.doi.org/10.1016/0024-3205(85)90519-3
Storlien LH;Grunstein HS;Smythe GA, 1985, 'Guanethidine blocks the 2-deoxy-d-glucose-induced hypothalamic noradrenergic drive to hyperglycemia', Brain Research, vol. 335, pp. 144 - 147, http://dx.doi.org/10.1016/0006-8993(85)90285-9
Storlien LH;Higson FM;Gleeson RM;Smythe GA;Atrens DM, 1985, 'Effects of chronic lithium, amitriptyline and mianserin on glucoregulation, corticosterone and energy balance in the rat', Pharmacology, Biochemistry and Behavior, vol. 22, pp. 119 - 125, http://dx.doi.org/10.1016/0091-3057(85)90494-0
Myers WD;Mackenzie L;Ng KT;Singer G;Smythe GA;Duncan MW, 1985, 'Salsolinol and dopamine in rat medial basal hypothalamus after chronic ethanol exposure', Life Sciences, vol. 36, pp. 309 - 314, http://dx.doi.org/10.1016/0024-3205(85)90115-8
Ho KY;Smythe GA;Lazarus L, 1985, 'Studies on the central and peripheral dopaminergic control of prl secretion in man: Failure to demonstrate the existence of a dopamine-mediated prolactin-inhibiting factor', Neuroendocrinology, vol. 40, pp. 457 - 462, http://dx.doi.org/10.1159/000124115
Smythe GA;Duncan MW, 1985, 'Precise GC/MS assays for salsolinol and tetrahydropapaveroline: the question of artifacts and dietary sources and the influence of alcohol.', Progress in clinical and biological research, vol. 183, pp. 77 - 84
Myers WD;Ng KT;Singer G;Smythe GA;Duncan MW, 1985, 'Dopamine and salsolinol levels in rat hypothalami and striatum after schedule-induced self-injection (SISI) of ethanol and acetaldehyde', Brain Research, vol. 358, pp. 122 - 128, http://dx.doi.org/10.1016/0006-8993(85)90955-2
Grunstein HS;Smythe GA;Storlien LH;Westermark P;Wilander E, 1985, 'NON-INSULIN-DEPENDENT DIABETES', The Lancet, vol. 326, pp. 104 - 105, http://dx.doi.org/10.1016/S0140-6736(85)90212-0
Grunstein HS;James DE;Storlien LH;Smythe GA;Kraegen EW, 1985, 'Hyperinsulinemia suppresses glucose utilization in specific brain regions: In Vivo studies using the euglycemic clamp in the rat', Endocrinology, vol. 116, pp. 604 - 610, http://dx.doi.org/10.1210/endo-116-2-604
Duncan MW;Smythe GA;Clezy PS, 1985, 'Gas chromatographic/mass spectrometric methodology for simultaneous assay of salsolinol, dopamine, norepinephrine, dihydroxyphenylacetic acid and dihydroxyphenylethanol', Biological Mass Spectrometry, vol. 12, pp. 106 - 114, http://dx.doi.org/10.1002/bms.1200120304
Ho KY;Smythe GA;Duncan M;Lazarus L, 1984, 'Dopamine Infusion Studies in Patients with Pathological Hyperprolactinemia: Evidence of Normal Prolactin Suppressibility but Abnormal Dopamine Metabolism', Journal of Clinical Endocrinology and Metabolism, vol. 58, pp. 128 - 133, http://dx.doi.org/10.1210/jcem-58-1-128
HO KY;SMYTHE GA;LAZARUS L, 1984, 'DOPAMINERGIC CONTROL OF GONADOTROPHIN SECRETION IN NORMAL WOMEN AND IN PATIENTS WITH PATHOLOGICAL HYPERPROLACTINAEMIA', Clinical Endocrinology, vol. 20, pp. 53 - 63, http://dx.doi.org/10.1111/j.1365-2265.1984.tb00059.x
Smythe GA;Grunstein HS;Bradshaw JE;Nicholson MV;Compton PJ, 1984, 'Relationships between brain noradrenergic activity and blood glucose', Nature, vol. 308, pp. 65 - 67, http://dx.doi.org/10.1038/308065a0
Duncan MW;Smythe GA;Nicholson MV;Clezy PS, 1984, 'Comparison of high-performance liquid chromatography with electrochemical detection and gas chromatography-mass fragmentography for the assay of salsolinol, dopamine and dopamine metabolites in food a', Journal of Chromatography B: Biomedical Sciences and Applications, vol. 336, pp. 199 - 209, http://dx.doi.org/10.1016/S0378-4347(00)85142-7
Ho KY;Smythe GA;Lazarus L, 1983, 'Prolactin Response to Dopamine Synthesis Inhibition Using Monoiodotyrosine in Subjects on Oral Contraceptives and Patients with Pathological Hyperprolactinemia', Journal of Clinical Endocrinology and Metabolism, vol. 56, pp. 692 - 696, http://dx.doi.org/10.1210/jcem-56-4-692
Smythe GA;Duncan MW;Bradshaw JE;Nicholson MV, 1983, 'Effects of 6-Methoxy-l, 2, 3, 4-tetrahydro-[β-carboline and yohimbine on hypothalamic monoamine status and pituitary hormone release in the rat', Australian Journal of Biological Sciences, vol. 36, pp. 379 - 386, http://dx.doi.org/10.1071/BI9830379
Smythe GA;Bradshaw JE;Vining RF, 1983, 'Hypothalamic monoamine control of stress-induced adrenocorticotropin release in the rat', Endocrinology, vol. 113, pp. 1062 - 1071, http://dx.doi.org/10.1210/endo-113-3-1062
Storlien LH;Bellingham WP;Smythe GA, 1983, 'Effect of guanethidine sympathectomy on intake and body weight of intact and LHA-lesioned rats', Physiology and Behavior, vol. 31, pp. 401 - 404, http://dx.doi.org/10.1016/0031-9384(83)90209-3
Smythe GA;Bradshaw JE, 1983, 'Different Acute Effects of the Tyrosine Hydroxylase Inhibitors α-Methyl-p-Tyrosine and 3-Iodo-L-Tyrosine on Hypothalamic Noradrenaline Activity and Adrenocorticotrophin Release in the Rat', Australian Journal of Biological Sciences, vol. 36, pp. 519 - 524, http://dx.doi.org/10.1071/BI9830519
Smythe GA;Ho K;Lazarus L, 1982, 'Prolactin levels and the response to central dopamine synthesis blockade in subjects on oral contraceptives', IRCS Medical Science, vol. 10, pp. 124
Smythe GA;Bradshaw JE;Cai WY;Symons RG, 1982, 'Hypothalamic serotoninergic stimulation of thyrotropin secretion and related brain-hormone and drug interactions in the rat', Endocrinology, vol. 111, pp. 1181 - 1191, http://dx.doi.org/10.1210/endo-111-4-1181
Smythe GA;Bradshaw JE;Duncan M, 1982, 'Loss of hypothalamic dopaminergic control of prolactin secretion in the hyperprolactinaemic rat', Australian Journal of Biological Sciences, vol. 35, pp. 207 - 213, http://dx.doi.org/10.1071/BI9820207
Johnson G;Hunt G;Smythe G, 1982, 'Clonidine induced growth hormone release in psychiatric patients', Neuroscience Letters, vol. 27
Smythe GA;Duncan MW;Bradshaw JE;Cai WY, 1982, 'Serotoninergic control of growth hormone secretion: Hypothalamic dopamine, norepinephrine, and serotonin levels and metabolism in three hyposomatotropic rat models and in normal rats', Endocrinology, vol. 110, pp. 376 - 383, http://dx.doi.org/10.1210/endo-110-2-376
Smythe GA;Ho K, 1981, 'Prolactin levels and the response to central dopamine synthesis blockade in subjects on oral contraceptives', Proceedings of the Endocrine Society of Australia, vol. Vol. 24, pp. 98
Smythe GA;Duncan MW;Bradshaw JE;Cai W, 1981, 'Direct evidence for central serotonin regulation of growth hormone (GH) secretion: Hypothalamic monoamine activity in pituitary GH-deficient rats and in rats hypo- or hypersecreting GH', Proceedings of the Endocrine Society of Australia, vol. Vol. 24, pp. 93
Smythe GA;Duncan MW;Bradshaw JE, 1981, 'Salsolinol is a potent stimulus for prolactin secretion in the rat: Evidence for hypothalamic dopamine blockade', IRCS Medical Science, vol. 9, pp. 472 - 473
Smythe GA;Duncan MW;Bradshaw JE, 1981, 'Putative brain alkaloids and pituitary function: A tetrahydroisoquinoline alkaloid derived from dopamine is a potent stimulus for prolactin secretion in the rat', Proceedings of the Endocrine Society of Australia, vol. Vol. 24, pp. 91
Smythe GA;Brandstater JF;Vining RF, 1981, 'Dexamethasone Concentrations in Plasma and Milk of Cows following the Injection of Long-and Short-acting Dexamethasone Esters', Australian Journal of Biological Sciences, vol. 34, pp. 321 - 324, http://dx.doi.org/10.1071/BI9810321
Vining RF;Smythe GA;Long MA, 1981, 'Deuterium exchange labelling of biologically important phenols, indoles and steroids', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 18, pp. 1683 - 1692, http://dx.doi.org/10.1002/jlcr.2580181114
Clezy PS;Fookes CJ R;Smythe GA, 1981, 'Chemistry of Pyrrolic Compounds. XLVIII The Chemistry of Porphyrins Carrying Sulfur-Containing Substituents at a meso-Carbon', Australian Journal of Chemistry, vol. 34, pp. 2595 - 2606, http://dx.doi.org/10.1071/CH9812595
Smythe GA;McGinley R;Chisholm DJ;Lazarus L, 1980, 'Effect of leu-enkephalin on serum cortisol levels in man', Clinical and Experimental Pharmacology and Physiology, vol. 7, pp. 47 - 48
Smythe GA;Brandstater JF, 1980, 'Oestrogen-Induced Hyperprolactinaemia in the Rat: Reduced Concentrations of Hypothalamic Dopamine and the Effects of Bromocriptine', Australian Journal of Biological Sciences, vol. 33, pp. 329 - 340, http://dx.doi.org/10.1071/BI9800329
Smythe GA;Brandstater JF;Lazarus L, 1979, 'Acute Effects of Lithium on Central Dopamine and Serotonin Activity Reflected by Inhibition of Prolactin and Growth Hormone Secretion in the Rat', Australian Journal of Biological Sciences, vol. 32, pp. 329 - 334, http://dx.doi.org/10.1071/BI9790329
Sara VR;Rutherford R;Smythe GA, 1979, 'The influence of maternal somatostatin administration on fetal brain cell proliferation and its relationship to serum growth hormone and brain trophin activity', Hormone and Metabolic Research, vol. 11, pp. 147 - 149, http://dx.doi.org/10.1055/s-0028-1092697
Smythe GA;Brandstater JF;Lazarus L, 1979, 'Hypothalamic dopamine, noradrenaline and serotonin in oestrogen-induced hyperprolactinaemia in the rat: Effects of bromocryptine', Proceedings of the Endocrine Society of Australia, vol. Vol. 22
Smythe GA;Brandstater JF, 1979, 'Serum Prolactin.and Brain and Pituitary Monoamine Responses to Chronic Monoamine Oxidase Inhibition in the Rat', Australian Journal of Biological Sciences, vol. 32, pp. 543 - 548, http://dx.doi.org/10.1071/BI9790543
Smythe GA;Brandstater JF;Bradshaw JE;Lazarus L, 1979, 'A Simple Procedure for the Assay of Brain Biogenic Amines by Selected-Ion Monitoring: Its Application to the Elucidation of the Mechanism of Prolactin Release Induced by 3-Iodo-L-Tyrosine', Australian Journal of Biological Sciences, vol. 32, pp. 335 - 342, http://dx.doi.org/10.1071/BI9790335
Smythe GA;Bradshaw J;Brandstater JF, 1978, 'The effect of altered brain dopamine levels on growth hormone release in the rat', Proceedings of the Endocrine Society of Australia, vol. VOL. 21, pp. 40
Judd S;Lazarus L;Smythe G, 1977, 'Bromo-ergocryptine: Mediaeval medicine revisited', Bulletin of the Postgraduate Committee in Medicine, University of Sydney, vol. 33, pp. 2 - 7
Smythe GA, 1977, 'Hypothalamic control of pituitary growth hormone secretion', Proceedings of the Endocrine Society of Australia, vol. Vol. 20
Smythe GA;Brandstater JF;Duncan M;Lazarus L, 1977, 'Serotoninergic pathways of growth hormone stimulation by morphine and LEU5enkephaline', Proceedings of the Endocrine Society of Australia, vol. Vol. 20, pp. 24
Lazarus L;Stuart C;Smythe GA, 1977, 'A study of the clinical growth hormone prolactin and somatomedin responses to bromocriptine therapy in patients with acromegaly', Proceedings of the Endocrine Society of Australia, vol. Vol. 20, pp. 26
Smythe GA;Brandstater JF;Compton PJ;Lazarus L, 1977, 'In vivo and in vitro inhibition of monoamine oxidase activity in the rat by 2 bromo-α-ergocryptine', Proceedings of the Endocrine Society of Australia, vol. Vol. 20, pp. 12
SMYTHE GA, 1977, 'THE ROLE OF SEROTONIN AND DOPAMINE IN HYPOTHALAMIC‐PITUITARY FUNCTION', Clinical Endocrinology, vol. 7, pp. 325 - 341, http://dx.doi.org/10.1111/j.1365-2265.1977.tb01331.x
Campbell LV;Smythe G;Lazarus L;Kraegen EW, 1977, 'BIOGENIC AMINES and GLUCAGON RELEASE', Australian and New Zealand Journal of Medicine, vol. 7, pp. 686 - 687, http://dx.doi.org/10.1111/j.1445-5994.1977.tb02387.x
Stuart M;Lazarus L;Smythe GA;Moore S;Sara V, 1976, 'Biogenic amine control of growth hormone secretion in the fetal and neonatal rat', Neuroendocrinology, vol. 22, pp. 337 - 342, http://dx.doi.org/10.1159/000122642
Smythe GA;Compton PJ;Lazarus L, 1976, 'Serotoninergic control of human growth hormone secretion: the actions of L dopa and 2 bromo α ergocryptine', EXCERPTA MED. I.C.S., vol. No. 381, pp. 222 - 235
Stuart MC;Lazarus L;Moore SS;Smythe GA, 1976, 'Somatomedin production in the neonatal rat', Hormone and Metabolic Research, vol. 8, pp. 442 - 445, http://dx.doi.org/10.1055/s-0028-1093610
Judd SJ;Lazarus L;Smythe G, 1976, 'Prolactin secretion by metoclopramide in man', Journal of Clinical Endocrinology and Metabolism, vol. 43, pp. 313 - 317, http://dx.doi.org/10.1210/jcem-43-2-313
Judd SJ;Smythe G;Compton P, 1976, 'Prolactin secretion by metoclopramide in man', Australian and New Zealand Journal of Medicine, vol. 6, pp. 254
Smythe GA;Brandstater JF;Lazarus L, 1975, 'The acute effects of lithium on central dopamine and serotonin activity as reflected by inhibition of prolactin and growth hormone secretion in the rat', Proceedings of the Endocrine Society of Australia, vol. Vol.18, pp. 50
O'Keeffe DH;Barlow CH;Smythe GA;Fuchsman WH;Moss TH;Lilienthal HR;Caughey WS, 1975, 'Magnetic and spectroscopic probes for FeOFe linkages in hemin systems', Bioinorganic Chemistry, vol. 5, pp. 125 - 147, http://dx.doi.org/10.1016/S0006-3061(00)80056-3
Stuart M;Lazarus L;Moore S;Smythe G, 1975, 'Growth hormone somatomedin interrelationships in hepatic cirrhosis', Proceedings of the Endocrine Society of Australia, vol. Vol.18, pp. 30
Smythe GA;Compton PJ;Lazarus L, 1975, 'The stimulation of human prolactin secretion by 3-iodo-L-tyrosine', Journal of Clinical Endocrinology and Metabolism, vol. 40, pp. 714 - 716, http://dx.doi.org/10.1210/jcem-40-4-714
Smythe GA;Brandstater JF;Lazarus L, 1975, 'Serotoninergic control of rat growth hormone secretion', Neuroendocrinology, vol. 17, pp. 245 - 257, http://dx.doi.org/10.1159/000122360
Caughey WS;Smythe GA;O'Keeffe DH;Maskasky JE;Smith MI, 1975, 'Heme A of cytochrome c oxidase. Structure and properties: comparisons with hemes B, C, and S and derivatives', Journal of Biological Chemistry, vol. 250, pp. 7602 - 7622
Smythe GA;Kraegen EW;Lazarus L, 1975, 'Dynamic perifusion studies of pineal gland function', Proceedings of the Endocrine Society of Australia, vol. Vol.18, pp. 52
Smythe GA;Lazarus L, 1974, 'Suppression of human growth hormone secretion by melatonin and cyproheptadine', Journal of Clinical Investigation, vol. 54, pp. 116 - 121, http://dx.doi.org/10.1172/JCI107732
Smythe GA;Lazarus L, 1974, 'Growth hormone responses to melatonin in man', Science, vol. 184, pp. 1373 - 1374
Smythe GA;Brandstater JF;Lazarus L, 1974, 'Rapid induction of prolactin secretion by 3 iodo L tyrosine', Neuroendocrinology, vol. 14, pp. 362 - 364, http://dx.doi.org/10.1159/000122281
Smythe GA;Stuart MC;Lazarus L, 1974, 'Stimulation and suppression of somatomedin activity by serotonin and melatonin', Experientia, vol. 30, pp. 1356 - 1357, http://dx.doi.org/10.1007/BF01945227
Clezy PS;Fookes CJ R;Lau DY K;Nichol AW;Smythe GA, 1974, 'The chemistry of pyrrolic compounds. XXV. The chemistry of acetal and thioacetal derivatives of pyrrolic systems', Australian Journal of Chemistry, vol. 27, pp. 357 - 369, http://dx.doi.org/10.1071/CH9740357
Smythe GA;Brandstater JF;Lazarus L, 1974, 'The control of growth hormone release by serotonin and its derivatives', Proceedings of the Endocrine Society of Australia, vol. Vol. 17, pp. 48
Smythe GA;Lazarus L, 1973, 'Serotoninergic control of growth hormone secretion in the rat and in man', PROC.ENDOCR.SOC.AUST., vol. Vol. 16, pp. 11
Smythe GA;Compton PJ;Lazarus L, 1973, 'The biogenic amine control of corticosteroid secretion', PROC.ENDOCR.SOC.AUST., vol. Vol. 16, pp. 12
Smythe GA;Lazarus L, 1973, 'Growth hormone regulation by melatonin and serotonin', Nature, vol. 244, pp. 230 - 231, http://dx.doi.org/10.1038/244230a0
Smythe GA;Lazarus L, 1973, 'Blockade of the dopamine-inhibitory control of prolactin secretion in rats by 3, 4-dimethoxyphenylethylamine (3, 4-di-O-methyldopamine)', Endocrinology, vol. 93, pp. 147 - 151, http://dx.doi.org/10.1210/endo-93-1-147
Smythe GA;Finlayson J;Lazarus L, 1973, 'Dopaminergic control of prolactin secretion: structure function relationships', PROC.ENDOCR.SOC.AUST., vol. Vol. 16, pp. 13
Smythe GA;Lazarus L, 1973, 'Blockade of serotonin induced GH secretion in rats by melatonin and cyproheptadine.', Hormone and Metabolic Research, vol. 5, pp. 227
Moss TH;Lillienthal HR;Moleski C;Smythe GA;McDaniel MC;Caughey WS, 1972, 'Exchange coupling in binuclear oxy-bridged iron(III) protoporphyrin IX dimethyl ester', Journal of the Chemical Society, Chemical Communications, pp. 263 - 264, http://dx.doi.org/10.1039/C39720000263
Smythe GA;Caughey WS, 1970, 'The structure and reactions of heme A of cytochrome c oxidase', Journal of the Chemical Society D: Chemical Communications, pp. 809 - 811, http://dx.doi.org/10.1039/C29700000809
Clezy PS;Liepa JA;Nichol AW;Smythe GA, 1970, 'The chemistry of pyrrolic compounds: IX. The synthesis of 5,5'-diformyldipyrrylketones and their derivatives', Australian Journal of Chemistry, vol. 23, pp. 589 - 602, http://dx.doi.org/10.1071/CH9700589
Clezy PS;Liepa AJ;Smythe GA, 1970, 'The chemistry of pyrrolic compounds: X. A contributiok to the chemistry of the oxyporphyrins', Australian Journal of Chemistry, vol. 23, pp. 603 - 618, http://dx.doi.org/10.1071/CH9700603
Clezy PS;Smythe GA, 1969, 'The chemistry of pyrrolic compounds: VIII. Dipyrrylthiones', Australian Journal of Chemistry, vol. 22, pp. 239 - 249, http://dx.doi.org/10.1071/CH9690239
Clezy PS;Smythe GA, 1968, 'A sulphur analogue of the oxyporphyrins', Chemical Communications (London), pp. 127 - 128, http://dx.doi.org/10.1039/C19680000127
Clezy PS;Looney FD;Nichol AW;Smythe GA, 1966, 'The Chemistry of Pyrrolic Compounds. III. The Free Radical Nature of the Oxyporphyrins', Australian Journal of Chemistry, vol. 19, pp. 1481 - 1486, http://dx.doi.org/10.1071/CH9661481
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