Gas Chromatography / Mass Spectrometry

Low Molecular Weight: Analysis of Small Molecules including Metabolomic Analysis

While electron ionisation (EI) coupled with GC/MS is the main technique for volatile compounds, the BMSF has expertise in a particularly sensitive and selective method based on negative ion mass spectrometry. This involves tagging the molecules of interest with a group that makes those molecules capture electrons and so form negative ions. The electron capture negative ion MS technique (ECNI MS) can be used effectively for many metabolite/marker and clinical mass spectrometry studies. Polar small molecules (involatile) are analysed by LC/MS (see below) using ionisation methods such as ESI and APCI. These methods are often useful in environmental analysis, metabolite analysis etc.

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Agilent HP 5973 MSD A & B

Gas Chromatography-mass spectrometry (GC-MS) combines two powerful analytical tools: gas chromatography for the highly efficient gas-phase separation of components in complex mixtures, and mass spectrometry for the confirmation of identity of these components as well as for the identification of unknowns. The HP 6890-5973 GC/MSD allows the analysis of small molecules (m/z 50-800) in a wide range of sample matrices. This system can be operated in electron ionisation (EI) and chemical ionisation (CI) modes.

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Thermo Focus DSQ

The Thermo DSQ II GC-MS instruments are our most up-to-date instruments for analysis of compounds that are sufficiently volatile to enter the gas phase intact. The Focus DSQ II GC-MS instrument at our Lower Campus mass spectrometry facility is configured as an electron impact (EI+) only system and is dedicated to analysis of gaseous environmental samples and for trace level analysis of underivatised volatile organic molecules in solution.

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Thermo Trace DSQ

The Thermo DSQ II GC-MS instruments are our most up-to-date instruments for analysis of compounds that are sufficiently volatile to enter the gas phase intact. The Mass Spectrometer of the Trace DSQ II GC-MS instrument at our Upper Campus facility can be operated in either electron impact (EI+) positive ionization mode, positive ion chemical ionization (CI+) mode, or electron capture negative ionization mode (ECNI or CI-). The Quadrupole MS gives nominal m/z assignments, accurate to +/- 0.2 Da.

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Thermo TSQ XLS

The TSQ XLS is a triple quadrpole mass spectrometer and it is equipped with gas chromatographic sample separation.  The instrument is capable of Electron Impact and Chemical Ionization modes and can operate in either positive and negative ion polarities.  The instrument is used predominately for small molecule quantitiave analysis.

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