Muromachi

Conventional tissue fixation methods make it difficult to take accurate neurochemical measurements in the brain due to rapid changes in the concentration of metabolites post-mortem caused by residual enzyme activity. The Muromachi microwave fixation system offers an effective way to inactivate these enzymes in the intact specimen. When sufficient microwave power is focused on the target, all enzymes within the tissue can be completely inactivated in less than 1 second. This fixation also allows the brain to be dissected easily and reproducibly at room temperature and allows effective measurement of acetylcholine, choline, cyclic AMP, cyclic GMP, GABA, DOPA, 5-HTP, serotonin, endorphin, phosphorylated proteins prostaglandin, catecholamines and their metabolites in the brain.

Contact People

Dr Carl A Power

Dr Carl A Power

Position: Head of BRIL
Facility: Biological Resources Imaging Laboratory
Category: Academic Staff

As head of BRIL, Dr Power has diverse interests in Preclinical imaging techniques including MRI, PET, CT, Optical Imaging and Ultrasound.

Full profile

Mr Brendan Lee

Mr Brendan Lee

Position: Technical Officer
Facility: Biological Resources Imaging Laboratory
Category: General/Technical Staff
Laboratory: Imaging

Brendan specialises in live animal imaging and related procedures including various surgeries, physiological monitoring and contrast/radioisotope administration.

Full profile