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IncuCyte FLR

Fluorescence Phase Contrast Widefield High Throughput

The IncuCyte FLR is a widefield inverted live cell system engineered with long term high throughput imaging in mind. Housed inside a tissue culture incubator, the imaging module maintains the most stable imaging conditions possible, and also comes with a selection of versatile inserts allowing you to imagine your cells in a range of vessels.

IncuCyte S3

Fluorescence Phase Contrast Widefield High Throughput

he IncuCyte S3 is a widefield inverted live cell system engineered with long term high throughput imaging in mind. Housed inside a tissue culture incubator, the imaging module maintains the most stable imaging conditions possible ( 37C temperature, humidity and 5% CO2). The system comes with a selection of versatile inserts allowing you to image your cells in a range of vessels.

Inveon MicroPET-CT

The Inveon μCT uses multiple axial x-rays of the animal to generate cross-sectional information or 3-dimensional reconstructions of the animal or parts of the animal. The μPET uses an LSO detector for fast scintillation decay time, high light output and effective atomic number.

iThera Multispectral Optoacoustic Tomography

Optoacoustic or photoacoustic imaging is a new, cutting-edge imaging technique which detects ultrasound waves following light absorption from specific molecules.  This technique allows molecules with different spectral profile to be detected.

IVIS Lumina and IVIS SpectrumCT

The IVIS Lumina provides a highly sensitive means to image fluorescent and/or bioluminescent reporters in vivo and in vitro. The IVIS SpectrumCT expands upon optical imaging capabilities as well as providing a microCT capability for anatomical referencing.

JPK Nanowizard 4 XP with Hybrid stage

AFM

The NanoWizard® 4 XP atomic force microscope is an advanced Atomic Force Microscope (AFM). AFM is a very high-resolution type of Scanning probe microscopy (SPM) which acquires data by “feeling” or “touching” the surface of a sample with a mechanical probe

 

Leica Bond Rx (UNSW & Ramaciotti)

Specimen Preperation

The BOND RX provides an easy way to automate the preparation of samples. In combination with PerkinElmer Opal™ Kit it is also useful for multiplexing allowing up to 9 fluorescent labels within a single sample.

Leica DM IL

Fluorescence Widefield

The Leica DM IL microscope is used to illuminate whole cells; observing and analysing a cell as a single entity. The DM IL is an inverted epifluorescence microscope, with transmitted light LED back illumination and an EL6000 Fluoro system.

Leica RM2135 Rotary Microtome

Specimen Preperation

Leica RM2135 rotary microtome is used to cut very thin cross-sections of specimens (usually 4 µm) for routine and research histology studies in the fields of biology and medicine.  This instrument is designed for cutting soft and harder paraffin embedded specimens, as long as they are suitable for being cut manually.  The sectioning thickness setting range can be from 1 µm to 60 µm.  High quality paraffin sections could be used for varying staining, such as Haematoxylin and Eosin stain (H&E), immunohistochemistry (IHC), Immunofluorescent staining (IF) and In situ hybridization (ISH).

Leica SP8 DLS

Confocal Lightsheet

The Leica TCS SP8 DLS (Digital LightSheet) is an inverted laser scanning microscope capable to be used for confocal imaging and light sheet imaging. This microscope is able to image multi-colour, live, fixed or aqueous-based cleared specimens utilising a combinations of 405, 458, 488, 514, 561 and 635 nm excitation lasers through the employment of the AOBS with spectral high quantum efficiency detectors. The advantage of the two combined features (confocal/Lightsheet) on a single equipment allow to perform, with the confocal module, local photo activation or photo bleaching where the resulting dynamics can be capture via lightsheet imaging on thick sample (up to 2 mm thick and 1 cm long).

Leica TCS SP5 WLL STED

Confocal FLIM

This Leica TCS SP5 confocal system is equipped for a broad range of experimental requirements. Along with a range of fixed wavelength laser lines it now has a White-Light Laser (WLL) tunable within the range x-x for precise control over fluorophore excitation. Fitted with Hybrid Dectors (HyD) for enhanced sensitivity, and interchangeable Galvano and resonant scanners, this system is suitable for applications requiring both speed and/or improved signal-to-noise. Its Gated-STED module also enables collection of super-resolution images allowing investigators to distinguish objects and structures beyond the conventional resolution limit of light.

MILabs U-CT

The MILabs U-CT installed in 2019 is a cutting-edge preclinical micro-CT scanner which has expanded BRIL's imaging capabilities by allowing larger sample sizes and shorter scan times.

Momentum Magnetic Particle Imaging

Magnetic Particle Imaging (MPI) is an emerging molecular imaging modality that measures the location and concentration of superparamagnetic nanoparticle tracers in vivo (typically Iron Oxide, SPIOs) by detecting their response to spatially dependent magnetic fields. In Q1 2020 UNSW has installed a Magnetic Insight Momentum pre-clinical MPI scanner as the first facility in Australia to provide this novel technology.

Muromachi Microwave Fixation System

The Muromachi microwave fixation system offers an effective way to inactivate these enzymes in the intact specimen.

Nikon A1 Intravital

Confocal Intravital

The Nikon A1 intravital microscope is an inverted confocal system designed for fast stable imaging over time. With two scanners, a standard Galvano scanner for achieving images with a high signal-to-noise ratio and a resonant scanner for when speed is of upmost importance, this system is suitable for a wide range of experiments. Equipped with 4 dedicated PMTs for reflective/fluorescence imaging, 2 of which as high efficiency GaAsP detectors, and a hardware solution (Perfect Focus System) for preventing drift during imaging this system yields both high sensitiy with speed and stability.