Instruments

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3i VIVO™ Microscope

3i VIVO™ Microscope

The 3i VIVO microscope is ideally suited for intravital imaging. Its large stable stage can easily accommodate sizable tissue samples along with clamps and manipulators to aid stabilization. Equipped with a spinning disk unit for high speed optical sectioning, paired with an image intensifier, this system can achieve very high frame rates making the most of every photon. Additionally, a pulsed 532nm ablation laser is available for targeted tissue damage. 

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Bruker Catalyst AFM

Bruker Catalyst AFM

The Bruker BioScope Catalyst™ Atomic Force Microscope (AFM) system can provide high resolution (nm) topographical data of biological systems such as living cells. The instrument works in tandem with an inverted optical microscope, which is also capable of fluorescence microscopy and has a heated stage for live cell imaging.

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Bruker Multimode 8

Bruker Multimode 8

The Bruker MultiMode® 8 (MM8) is an advanced atomic force microscope (AFM) and Scanning Tunnelling Microscope (STM). Its PeakForce Tapping technology enables exceedingly low tip-sample force interactions compared to tapping mode, making it particularly useful for delicate samples by allowing the user to control the maximal force imparted to the sample.

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Cri Nuance

Cri Nuance

The Cri Nuance system is a unique camera capable of spectral analysis and spectral unmixing. The camera is capable of detecting wavelengths between 450 and 950nm with < 10nm spectral resolution. We have linked the Nuance system to a Leica DMIRB inverted, epifluorescent microscope equipped with 3 excitation filters: a near UV (340-380 Band Pass), a blue (450-490nm), and a green (515-560).

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Fluoview FV1000

Fluoview FV1000

The olympus Fluoview FV1000 is a fluorescence confocal microscope. Unlike most confocal systems it is equipped with two scan heads allowing simultaneous imaging with photo-Activation/Bleaching. This makes it ideally suited for applications such as photoconversion, Fluorescence Recovery After Photobleaching (FRAP) and uncaging experiments.

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FluoView FV1200

FluoView FV1200

The FV1200 is a filter based upright confocal system. A workhorse of our confocal systems it is well equipped for standard fixed samples where high resolution and sensitivity are required for localization based studies. Additionally as one of the few upright confocal systems within the BMIF it provides a means for visualizing water submerged opaque samples.

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IncuCyte FLR

IncuCyte FLR

The IncuCyte FLR is a widefield inverted live cell system engineered with long term high throughput imaging in mind. Housed inside a tissue culture incubator, the imaging module maintains the most stable imaging conditions possible, and also comes with a selection of versatile inserts allowing you to imagine your cells in a range of vessels.

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Lavision TriM Scope II Multiphoton Intravital

Lavision TriM Scope II Multiphoton Intravital

This intravital microscope boasts an impressive collection of hardware. Equipped with 2 multiphoton lasers utilising a pre-chirp compensator to keep laser pulse width < 150 fs, a collection of detectors including high sensitive NDD detectors close to the objective lens, descanned PMTs, imaging cameras for fast 64 beam scanning and also LaVision BioTec's FLIM x16 TCSPC detector for rappid fluorescence lifetime measurements. 

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Leica DM IL

Leica DM IL

The Leica DM IL microscope is used to illuminate whole cells; observing and analysing a cell as a single entity. The DM IL is an inverted epifluorescence microscope, with transmitted light LED back illumination and an EL6000 Fluoro system.

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Leica TCS SP5 MP STED

Leica TCS SP5 MP STED

Leica TCS SP5 equipped with multiphoton Ti-Sapphire laser is an inverted confocal laser scanning microscope. It is designed for high-resolution fluorescence and transmitted light imaging with single or multi-photon excitation, in 2D, 3D or 4D with live or fixed cells. It can also be used for Fluorescence Recovery After Photo bleaching (FRAP), pulsed Stimulated Emission Depletion (pulsed STED) and Fluorescence Correlation Spectroscopy (FCS).

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Leica TCS SP5 WLL STED

Leica TCS SP5 WLL STED

This Leica TCS SP5 confocal system is equipped for a broad range of experimental requirements. Along with a range of fixed wavelength laser lines it now has a White-Light Laser (WLL) tunable within the range x-x for precise control over fluorophore excitation. Fitted with Hybrid Dectors (HyD) for enhanced sensitivity, and interchangeable Galvano and resonant scanners, this system is suitable for applications requiring both speed and/or improved signal-to-noise. Its Gated-STED module also enables colleciton of super-resolution images allowing investigators to distinguish objects and structures beyond the conventional resolution limit of light.

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Nikon A1 Intravital

Nikon A1 Intravital

The Nikon A1 intravital microscope is an inverted confocal system designed for fast stable imaging over time. With two scanners, a standard Galvano scanner for achieving images with a high signal-to-noise ratio and a resonant scanner for when speed is of upmost importance, this system is suitable for a wide range of experiments. Equipped with 4 dedicated PMTs for reflective/fluorescence imaging, 2 of which as high efficiency GaAsP detectors, and a hardware solution (Perfect Focus System) for preventing drift during imaging this system yields both high sensitiy with speed and stability. 

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Nikon Biostation

Nikon Biostation

Nikon Biostation is an inverted life cell imaging microscope enclosed in an incubator. The stage and objective are fully enclosed in temperature modulated box resulting in no focus drift during imaging. The cells are kept at 37C and supplemented with 5% CO2 throughout the entire experiment. The imaging chamber can hold 35mm glass or plastic bottom dishes of 0.17um thickness. The Biostation is an ideal microscope for imaging cell migrations, wound healing, cell division and cell growth and adherence.

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Nikon Eclipse Tie

Nikon Eclipse Tie

The Nikon Eclipse TiE is ideally suited for live cell imaging studies. With one of the best focus stabilisation devices on the market the Perfect Focus System (PFS) ensures that the focus you set at the start of the experiment will be maintained throughout its entirety. They system is fitted with several phase contrast objects making it suitable for imaging cells through a range of materials including plastic, as well as 3 high NA DIC objects for achieving astounding detail if imaging through glass.

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Picoquant Microtime200

Picoquant Microtime200

The Microtime200, manufactured by the German-based PicoQuant GmbH, is generally used in conjunction with the TCS SP5 microscope. By using the lasers from the TCS SP5, the Microtime200 is capable of measuring how fast proteins move within the cell (diffusion) and protein to protein interactions.

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TILL Photonics iMic TIRF System

TILL Photonics iMic TIRF System

This microscope has a unique design, allowing for a great deal of customization of the sample space and experimental design. The system is designed for up to four-color total internal fluorescence (TIRF), photoactivation (PA), fluorescence resonance energy transfer (FRET), widefield correlation spectroscopy (WCS), spatio-temporal image correlation spectroscopy (STICS), and fluorescence recovery after photobleaching (FRAP) experiments, all at high frame rates. Single-molecule measurements can be enhanced with a pair of single-photon avalanche photodiodes (APDs) and a pulse correlator for fluorescence correlation spectroscopy (FCS) and fluorescence cross-correlation spectroscopy (FCCS) experiments. An environmental chamber allows for these techniques to be extended to live cell samples.

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Zeiss Axio Observer X.1 SD & TIRF

Zeiss Axio Observer X.1 SD & TIRF

The zeiss Spinning Disk/TIRF system is a custom built instrument.  Built upon an Axio Observer X.1 body it is equipped with a Yokogawa Spinning disk CSU-X1 module providing confocal imaging at rapid frame rates captured on an EM CCD camera (Quant EM) ideally suited for low light imaging. Attached to a different microscope port is a highly sensitive high frame rate sCMOS camera (Orca Flash 4) which can be used for standard epifluorescence, rapid ratiometric imaging utilising a fast excitation switching light source (Lambda DG4) or acquire fluorescence images using TIRF illumination.

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Zeiss Elyra PALM/SIMS Superresolution

Zeiss Elyra PALM/SIMS Superresolution

The Zeiss Elyra Superresolution Microscope is a developmental superresolution microscope with capabilities to push imaging past the classic diffraction limit. Typically visible light microscopes cannot achieve spatial resolution of greater than 200-250 nanometers. This system has two different imaging modalities to push this limit as low as 20 nanometers.

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Zeiss Lightsheet Z.1

Zeiss Lightsheet Z.1

Lighsheet microscopy is a fluorescence-based imaging technique that is growing in popularity. It outperforms other techniques in its ability to rapidly capture large optically sectioned three dimensional datasets, whilst keeping photo-toxicity and bleaching to a minimum. It therefore lends itself well to imaging samples larger than those typically attempted by conventional fluorescence microscopy such as tissues, whole organs and even embryo development. 

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Zeiss LSM 780

Zeiss LSM 780

The Zeiss LSM 780 is a high-sensitivity laser scanning confocal microscope. Unlike most standard confocal systems this instrument comes equipped with a GaAsP photodetector. This detector in addition to boasting a quantum efficiency of 45% (in comparison to 25% for standard PMTs), it can also be used as a single-point detector or as a 32-channel detector array facilitating spectral measurements. It can also be switched into a single-photon counting mode providing great signal to noise for such techniques as FCS and RICS. 

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Zeiss LSM 880

Zeiss LSM 880

The Zeiss LSM 880 is an inverted laser scanning confocal microscope equipped with high quantum efficiency GaAsP detector and 2 multialkali PMTs, which can be used as single point detectors or combined for 34 channel spectral imaging. In addition, the Airyscan module can deliver images with 1.7 x improved resolution (140nm axially, 400 nm laterally) and 4-8 x greater signal-to-noise ratio, at the highest speed of any linear scanning confocal system. BiG.2 Type A (2x GaAsP detectors) non-descanned detectors for the multi-photon laser can be used for imaging thick specimens, with deeper penetration and decreased phototoxicity compared to single photon lasers. The Picoquant system utilises the multi-photon laser to perform Fluorescence Lifetime Imaging (FLIM), Fluorescence Correlation Spectroscopy (FCS), Forster Resonance Energy Transfer (FRET). The Zeiss 880 is also equipped with polarisers for anisotropy measurements. 

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