BSc(Hons)(Biochemistry), University of Sydney
PhD(Medical Sciences), UNSW Australia
Role & Interests
My research interests are focused on the mechanisms underlying Alzheimer’s disease, particularly in assessing oxidative damage to proteins in Alzheimer’s brain and plasma. A proteomics based approach is currently being implemented, involving separation of proteins by 2D PAGE, detection of oxidised proteins (carbonyls and 3-nitrotyrosine) using a combination of immunoaffinity and chemiluminescence detection. Oxidised proteins will be characterised using a combination of mass spectrometric techniques, including MALDI-TOF, ECNI-GC/MS, LC/MS and MS/MS. Further interests include quantification of changes in expression levels of proteins and peptides in Alzheimer’s dementia and in normal aging, and how they relate to mechanisms of disease.