Dr Ling Zhong


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I have over 10 years of hands-on experiences with a variety of sophisticated mass spectrometers. I am recognized for strong mass spectrometry based proteomics expertise. There are a number of proteomics areas that I am interested in and specialized on, including but no limited to, phosphorylation enrichment, phosphotyrosine immune-purification, MRM quantification, SILAC, iTRAQ analysis and label free quantification.



Book Chapters

Hu M; Lee M; Zhong L; Manefield MJ, 2019, 'Method Development for DNA and Proteome SIP Analysis of Activated Sludge for Anaerobic Dichloromethane Biodegradation', in Stable Isotope Probing, pp. 207 - 219, http://dx.doi.org/10.1007/978-1-4939-9721-3_16

Conference Abstracts

Dolai S; Sia KCS; Robbins AK; Zhong L; Heatley S; Vincent T; Hochgraefe F; Kurmasheva RT; White DL; Houghton PJ; Smith MA; Teachey DT; Daly RJ; Raftery MJ; Lock RB, 2014, 'Targeted Cancer Therapy in High-Risk Pediatric Leukemia Using Global Phosphotyrosine Profiling', in BLOOD, AMER SOC HEMATOLOGY, Vol. 124, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242705041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
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Jayasena T; Poljak A; Zhong L; Braidy N; Smythe G; Raftery M; Sachdev P, 2013, 'Development of a targeted mass spectrometry method for accurate quantification of human sirtuins in biological samples [Abstract P2-035]', in Alzheimer's & Dementia, Boston, MA, USA, Vol. 9, pp. P357 - P357, presented at Alzheimer’s Association International Conference (AAIC) 2013, Boston, MA, USA, 13 July 2013 - 18 July 2013, http://dx.doi.org/10.1016/j.jalz.2013.05.677

Conference Papers

Wang P; Yang JYH; Raftery M; Zhong L; Wilson S, 2013, 'Latin Square dataset for evaluating the accuracy of mass spectrometry-based protein identification and quantification', in He X (ed.), 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2013), Shanghai, China, pp. 65 - 67, presented at 2013 IEEE International Conference on Bioinformatics and Biomedicine, Shanghai, China, 18 December 2013 - 21 December 2013
Velonas VM; Raftery M; Zhong L; Poljak A; Assinder S; Woo H; Remedios CD, 2012, 'Peptide-based mass spectrometry identification of exosome proteins from prostate cancer cell lines', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Darwin, pp. 20 - 21, presented at 65th Annual Scientific Meeting on Urological-Society-of-Australia-and-New Zealand, AUSTRALIA, Darwin, 21 April 2012 - 24 April 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303003900030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles

Wong SL; Kardia E; Vijayan A; Umashankar B; Pandzic E; Zhong L; Jaffe A; Waters SA, 2023, 'Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms24076475
Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2023, 'Integrating proteomic data with metabolic modeling provides insight into key pathways of Bordetella pertussis biofilms', Frontiers in Microbiology, 14, http://dx.doi.org/10.3389/fmicb.2023.1169870
Mercier C; Thies D; Zhong L; Raftery MJ; Erdmann S, 2023, 'Characterization of an archaeal virus-host system reveals massive genomic rearrangements in a laboratory strain', Frontiers in Microbiology, 14, http://dx.doi.org/10.3389/fmicb.2023.1274068
Truong P; Shen S; Joshi S; Afrasiabi A; Zhong L; Raftery MJ; Larsson J; Lock RB; Walkley CR; Rokny HA; Thoms JAI; Jolly CJ; Pimanda JE, 2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', BLOOD, 140, http://dx.doi.org/10.1182/blood-2022-165713
Kaur G; Poljak A; Ali SA; Zhong L; Raftery MJ; Sachdev P, 2021, 'Extending the Depth of Human Plasma Proteome Coverage Using Simple Fractionation Techniques', Journal of Proteome Research, 20, pp. 1261 - 1279, http://dx.doi.org/10.1021/acs.jproteome.0c00670
Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453
Santiago FS; Li Y; Zhong L; Raftery MJ; Lins L; Khachigian LM, 2021, 'Truncated YY1 interacts with BASP1 through a 339KLK341motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury', Cardiovascular Research, 117, pp. 2395 - 2406, http://dx.doi.org/10.1093/cvr/cvab021
Awatade N; Wong S; Capraro A; Pandzic E; Slapetova I; Zhong L; Fawcett L; Whan R; Jaffe A; Waters S, 2021, 'Significant functional differences in differentiated Conditionally Reprogrammed (CRC)- and Feeder-free Dual SMAD inhibited-expanded human nasal epithelial cells', Journal of Cystic Fibrosis, 20, pp. 364 - 371, http://dx.doi.org/10.1016/j.jcf.2020.12.019
Bӧhm JW; Sia KCS; Jones C; Evans K; Mariana A; Pang I; Failes T; Zhong L; Mayoh C; Landman R; Collins R; Erickson SW; Arndt G; Raftery MJ; Wilkins MR; Norris MD; Haber M; Marshall GM; Lock RB, 2021, 'Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia', Leukemia, 35, pp. 3101 - 3112, http://dx.doi.org/10.1038/s41375-021-01248-8
An H; Richardson A; Rajasekariah P; Zhong L; Fernando BSM; Macmillan A; Klotzsch E; Bryant K; Kaakoush NO; Tedla N, 2021, 'Nuclear Leukocyte Immunoglobulin-like Receptor A3 Is Monomeric and Is Involved in Multiple Layers of Regulated Gene Expression and Translation', Journal of Proteome Research, 20, pp. 3078 - 3089, http://dx.doi.org/10.1021/acs.jproteome.0c00946
Luu LDW; Zhong L; Kaur S; Raftery MJ; Lan R, 2021, 'Comparative Phosphoproteomics of Classical Bordetellae Elucidates the Potential Role of Serine, Threonine and Tyrosine Phosphorylation in Bordetella Biology and Virulence', Frontiers in Cellular and Infection Microbiology, 11, http://dx.doi.org/10.3389/fcimb.2021.660280
Sia KCS; Zhong L; Mayoh C; Norris MD; Haber M; Marshall GM; Raftery MJ; Lock RB, 2020, 'Targeting TSLP-induced tyrosine kinase signaling pathways in CRLF2-Rearranged Ph-like ALL', Molecular Cancer Research, 18, pp. 1767 - 1776, http://dx.doi.org/10.1158/1541-7786.MCR-19-1098
Wang H; Leeming MG; Cochran BJ; Hook JM; Ho J; Nguyen GTH; Zhong L; Supuran CT; Donald WA, 2020, 'Nontargeted Identification of Plasma Proteins O-, N-, and S-Transmethylated by O-Methyl Organophosphates', Analytical Chemistry, 92, pp. 15420 - 15428, http://dx.doi.org/10.1021/acs.analchem.0c03077
Awatade N; Wong S; Pandzic E; Slapetova I; Capraro A; Zhong L; Turgutoglu N; Fawcett L; Whan R; Jaffe A; Waters S, 2020, 'Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells', , http://dx.doi.org/10.1101/2020.05.29.120006
Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S; Hart-Smith G; Zhong L; Pandzic E; Fernando BSM; Awatade N; Wong S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, 9, pp. 1 - 19, http://dx.doi.org/10.3390/antiox9121204
Luu LDW; Octavia S; Aitken C; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2020, 'Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens', Vaccine, 38, pp. 539 - 548, http://dx.doi.org/10.1016/j.vaccine.2019.10.062
Hewson C; Capraro A; Wong S; Pandzic E; Fernando BSM; Awatade N; Zhong L; Hart-Smith G; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model', , http://dx.doi.org/10.1101/2020.05.27.119990
Hamm JN; Erdmann S; Eloe-Fadrosh EA; Angeloni A; Zhong L; Brownlee C; Williams TJ; Barton K; Carswell S; Smith MA; Brazendale S; Hancock AM; Allen MA; Raftery MJ; Cavicchioli R, 2019, 'Unexpected host dependency of Antarctic Nanohaloarchaeota', Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 14661 - 14670, http://dx.doi.org/10.1073/pnas.1905179116
Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019
Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2019, 'Tu1872 – The Human Intestinal Proteome in Children with Cystic Fibrosis', Gastroenterology, 156, pp. S - 1153, http://dx.doi.org/10.1016/s0016-5085(19)39855-5
Daniel S; Nylander V; Ingerslev LR; Zhong L; Fabre O; Clifford B; Johnston K; Cohn R; Barres R; Simar D, 2018, 'T-cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors', Clinical Epigenetics, 10, pp. 138 - 138, http://dx.doi.org/10.1186/s13148-018-0561-5
Wai Luu LD; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Comparison of the whole cell proteome and secretome of epidemic bordetella pertussis strains from the 2008–2012 Australian epidemic under sulfate-modulating conditions', Frontiers in Microbiology, 9, http://dx.doi.org/10.3389/fmicb.2018.02851
Luu LDW; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Proteomic Adaptation of Australian Epidemic Bordetella pertussis', Proteomics, 18, http://dx.doi.org/10.1002/pmic.201700237
Begg DJ; de Silva K; Di Fiore L; Taylor DL; Bower K; Zhong L; Kawaji S; Emery D; Whittington RJ, 2018, 'Corrigendum to “Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis” [Veterinary Microbiology 141 (2010) 301-311] (Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis (2010) 141(3–4) (301–311), (S0378113509004088), (10.1016/j.vetmic.2009.09.007))', Veterinary Microbiology, 224, pp. 119, http://dx.doi.org/10.1016/j.vetmic.2018.08.023
Yau KPS; Murphy AB; Zhong L; Mai-Prochnow A, 2018, 'Cold plasma effect on the proteome of Pseudomonas aeruginosa-Role for bacterioferritin', PLoS ONE, 13, http://dx.doi.org/10.1371/journal.pone.0206530
Gardiner M; Bournazos AM; Maturana-Martinez C; Zhong L; Egan S, 2017, 'Exoproteome analysis of the seaweed pathogen Nautella italica R11 reveals temperature-dependent regulation of RTX-like proteins', Frontiers in Microbiology, 8, http://dx.doi.org/10.3389/fmicb.2017.01203
Erdmann S; Tschitschko B; Zhong L; Raftery MJ; Cavicchioli R, 2017, 'A plasmid from an Antarctic haloarchaeon uses specialized membrane vesicles to disseminate and infect plasmid-free cells', Nature Microbiology, 2, pp. 1446 - 1455, http://dx.doi.org/10.1038/s41564-017-0009-2
Luu LDW; Octavia S; Zhong L; Raftery M; Sintchenko V; Lan R, 2017, 'Characterisation of the Bordetella pertussis secretome under different media', Journal of Proteomics, 158, pp. 43 - 51, http://dx.doi.org/10.1016/j.jprot.2017.02.010
Strbenac D; Zhong L; Raftery MJ; Wang P; Wilson SR; Armstrong NJ; Yang JYH, 2017, 'Quantitative Performance Evaluator for Proteomics (QPEP): Web-based Application for Reproducible Evaluation of Proteomics Preprocessing Methods', Journal of Proteome Research, 16, pp. 2359 - 2369, http://dx.doi.org/10.1021/acs.jproteome.6b00882
Dolai S; Sia KCS; Robbins AK; Zhong L; Heatley SL; Vincent TL; Hochgräfe F; Sutton R; Kurmasheva RT; Revesz T; White DL; Houghton PJ; Smith MA; Teachey DT; Daly RJ; Raftery MJ; Lock RB, 2016, 'Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia', Cancer Research, 76, pp. 2766 - 2777, http://dx.doi.org/10.1158/0008-5472.CAN-15-2786
Jayasena T; Poljak A; Braidy N; Zhong L; Rowlands B; Muenchhoff J; Grant R; Smythe G; Teo C; Raftery M; Sachdev PS, 2016, 'Application of targeted mass spectrometry for the quantification of sirtuins in the central nervous system', Scientific Reports, 6, pp. 35391 - 35391, http://dx.doi.org/10.1038/srep35391
Tschitschko B; Williams TJ; Allen MA; Zhong L; Raftery MJ; Cavicchioli R, 2016, 'Ecophysiological distinctions of haloarchaea from a hypersaline Antarctic lake determined using metaproteomics.', Appl Environ Microbiol, 82, pp. 3165 - 3173, http://dx.doi.org/10.1128/AEM.00473-16
Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804
Tschitschko B; Williams TJ; Allen MA; Páez-Espino D; Kyrpides N; Zhong L; Raftery MJ; Cavicchioli R, 2015, 'Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation', The ISME Journal, 9, pp. 2094 - 2107, http://dx.doi.org/10.1038/ismej.2015.110
Gardiner M; Fernandes ND; Nowakowski D; Raftery M; Kjelleberg S; Zhong L; Thomas T; Egan S, 2015, 'VarR controls colonization and virulence in the marine macroalgal pathogen Nautella italica R11', Frontiers in Microbiology, 6, http://dx.doi.org/10.3389/fmicb.2015.01130
Masoudi S; Zhong L; Raftery MJ; Stapleton FJ; Willcox MD, 2014, 'Method development for quantification of five tear proteins using selected reaction monitoring (SRM) mass spectrometry', Investigative Ophthalmology and Visual Science, 55, pp. 767 - 775, http://dx.doi.org/10.1167/iovs.13-12777
Lee H; Ma R; Grimm MC; Riordan SM; Lan R; Zhong L; Raftery M; Zhang L, 2014, 'Examination of the anaerobic growth of Campylobacter concisus strains', International Journal of Microbiology, 2014, http://dx.doi.org/10.1155/2014/476047
Liao BM; Raddatz K; Zhong L; Parker BL; Raftery MJ; Schmitz-Peiffer C, 2014, 'Proteomic analysis of livers from fat-fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism', Proteomics, 14, pp. 2578 - 2587, http://dx.doi.org/10.1002/pmic.201400202
Fan L; Liu M; Zhong L; Kjelleberg S; Thomas T, 2012, 'Metaproteogenomic analysis of a community of sponge symbionts', ISME Journal, 6, pp. 1515 - 1525, http://dx.doi.org/10.1038/ismej.2012.1
Omali NB; Zhao Z; Zhong L; Raftery MJ; Zhu H; Ozkan J; Willcox MDP, 2012, 'Quantification of protein deposits on silicone hydrogel materials using stable-isotopic labeling and multiple reaction monitoring', Biofouling, 28, pp. 697 - 709, http://dx.doi.org/10.1080/08927014.2012.702763
Zhong L; Taylor D; Begg D; Whittington R, 2011, 'Biomarker discovery for ovine paratuberculosis (Johne's disease) by proteomic serum profiling', Comparative Immunology Microbiology and Infectious Diseases, 34, pp. 315 - 326, http://dx.doi.org/10.1016/j.cimid.2011.03.001
Begg DJ; de Silva K; Di Fiore L; Taylor DL; Bower K; Zhong L; Kawaji S; Emery D; Whittington RJ, 2010, 'Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis', Veterinary Microbiology, 141, pp. 301 - 311, http://dx.doi.org/10.1016/j.vetmic.2009.09.007
You J; Fitzgerald A; Cozzi PJ; Zhao Z; Graham PH; Russell PJ; Walsh B; Willcox MD; Ling Z; Wasinger VC; Li Y, 2010, 'Post-translation modification of proteins in tears', Electrophoresis, 31, pp. 1853 - 1861, http://dx.doi.org/10.1002/elps.200900755
You J; Fitzgerald A; Cozzi PJ; Zhao Z; Graham P; Russell PJ; Walsh BJ; Willcox M; Zhong L; Wasinger V; Li Y, 2010, 'Post‐translation modification of proteins in tears', PROTEOMICS – Clinical Applications, 4, pp. 870 - 870, http://dx.doi.org/10.1002/prca.201090087
Zhong L; Di Fiore L; Taylor D; Begg D; de Silva K; Whittington RJ, 2009, 'Identification of differentially expressed genes in ileum, intestinal lymph node and peripheral blood mononuclear cells of sheep infected with Mycobacterium avium subsp paratuberculosis using differential display polymerase chain reaction', VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 131, pp. 177 - 189, http://dx.doi.org/10.1016/j.vetimm.2009.04.007
Taylor D; Ling Z; Begg D; De Silva K; Whittington R, 2008, 'Toll-like receptor genes are differentially expressed at the sites of infection during the progression of Johne’s disease in outbred sheep', Veterinary Immunology and Immunopathology, 124, pp. 132 - 151
Ling Z; Taylor D; Whittington R, 2008, 'Proteomic profiling of ovine serum by SELDI-TOF MS: optimization, reproducibility and feasibility of biomarker discovery using routinely collected samples', Comparative Immunology Microbiology and Infectious Diseases


Mercier C; Thies D; Zhong L; Raftery MJ; Cavicchioli R; Erdmann S, 2022, In depth characterization of an archaeal virus-host system reveals numerous virus exclusion mechanisms, , http://dx.doi.org/10.1101/2022.10.18.512658
Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2022, Integrating proteomic data with metabolic modelling provides insight into key pathways ofBordetella pertussisbiofilms, , http://dx.doi.org/10.1101/2022.05.27.493021
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