Dr Russell Pickford

Research Fellow

Category: Academic Staff
Research profile: Click to view

Biography

Education

MChem(Chemistry), Sheffield University, UK
MSc(Analytical Chemistry), University of Warwick, UK
PhD(Chemistry), UMIST, UK

Role & Interests

The advancement of mass spectrometric techniques and their application to the solution of complex biological problems, particularly applied to the analysis of small molecules and metabolites; development of methods for metabolite profiling (metabolomics) and targeted (quantitative) metabolite analysis for specific applications; development of LC and sample preparation procedures to facilitate the MS analysis of small molecules in biological fluids; application of modern mass spectrometric methods, such as accurate mass measurement using FT-ICR and elemental composition calculations to identify unknown small molecules;incorporation of new advances in mass spectrometry, such as Desorption Electrospray Ionisation, into our laboratory and routine usage.

Curriculum Vitae

Publications

Book Chapters

Lim XY;Pickford R;Don AS, 2016, 'Assaying ceramide synthase activity in vitro and in living cells using liquid chromatography-mass spectrometry', in Methods in Molecular Biology, pp. 11 - 22, http://dx.doi.org/10.1007/978-1-4939-3170-5_2

Conference Abstracts

Unnikrishnan A;Quynh AV N;Pickford R;Nunez A;Hesson L;Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Madrid, SPAIN, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, Madrid, SPAIN, 22 - 25 June 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404127002145&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
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Kim W;Jary E;Pickford R;Bartley L;Piguet O;Hodges J;Halliday G, 2016, 'Alteration in plasma lipids in frontotemporal dementia', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Munich, GERMANY, Vol. 138, pp. 399 - 400, presented at 10th International Conference on Frontotemporal Dementias, Munich, GERMANY, 31 August - 02 September 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000382568400455&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Harrison-Tikisci Z;von Jonquieres G;Rowlands B;Klugmann C;Delarue F;Ittner L;Pickford R;Housley G;Rae C;Klugmann M, 2015, 'N-acetylaspartate: genomics, phenomics and metabonomics', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 141 - 141, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australa, Cairns, AUSTRALIA, 23 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300323&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers

Fedorow HS;Garner B;Pickford R;Hook JM;Kettle E;Cartwright HR;Double KL;Gerlach M;Riederer P;Halliday GM, 2005, 'Investigations of the lipid component of neuromelanin', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Berlin, Germany, pp. 58 - 58, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 - 09 June 2005
Fedorow HS;Pickford R;Hook J;Double KL;Halliday GM;Gerlach M;Riederer P;Garner B, 2005, 'Dolichol is the major lipid component of neuromelanin in human substanta nigra', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Berlin, Germany, pp. 107 - 107, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 - 09 June 2005
Vishnumohan S;Pickford R;Smythe GA;Arcot J, 2005, 'A sensitive and selective method for quantification of natural folates in foods using electrospray tandem MS', in Proceedings of the Nutrition Society of Australia, National Society of Australia (NSA), Melbourne, presented at Nutrition Society of Australia (2005), Melbourne, 30 November - 03 December 2005
Fedorow HS;Pickford R;Hook JM;Double KL;Halliday GM;Gerlach M;Riederer P;Garner B, 2005, 'Identification of the major lipid component of neuromelanin in human dopamine neurons', in Proceedings of Aust Neuroscience Society, 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, pp. 139 - 139, presented at 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, 30 January - 02 February 2005

Conference Posters

Chandra-hioe M;Bucknall MP;Pickford R;Arcot J, 2010, 'The levels of Folic Acid and 5-Methyl Tetra Hydrofolate in Australian fortified bread', Copenhagen, presented at 1st International Vitamin Conference, Copenhagen, 19 - 21 May 2010

Journal articles

Wong MW K;Braidy N;Pickford R;Vafaee F;Crawford J;Muenchhoff J;Schofield P;Attia J;Brodaty H;Sachdev P;Poljak A, 2019, 'Plasma lipidome variation during the second half of the human lifespan is associated with age and sex but minimally with BMI', PLoS ONE, vol. 14, http://dx.doi.org/10.1371/journal.pone.0214141
D'Agostino PM;Woodhouse JN;Liew HT;Sehnal L;Pickford R;Wong HL;Burns BP;Neilan BA, 2019, 'Bioinformatic, phylogenetic and chemical analysis of the UV-absorbing compounds scytonemin and mycosporine-like amino acids from the microbial mat communities of Shark Bay, Australia', Environmental Microbiology, vol. 21, pp. 702 - 715, http://dx.doi.org/10.1111/1462-2920.14517
Atashrazm F;Hammond D;Perera G;Dobson-Stone C;Mueller N;Pickford R;Kim WS;Kwok JB;Lewis SJ G;Halliday GM;Dzamko N, 2018, 'Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-33921-x
Unnikrishnan A;Vo AN Q;Pickford R;Raftery MJ;Nunez AC;Verma A;Hesson LB;Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, vol. 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340
Aw WC;Towarnicki SG;Melvin RG;Youngson NA;Garvin MR;Hu Y;Nielsen S;Thomas T;Pickford R;Bustamante S;Vila-Sanjurjo A;Smyth GK;Ballard JW O, 2018, 'Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness', PLoS Genetics, vol. 14, http://dx.doi.org/10.1371/journal.pgen.1007735
Giardina M;Cheong S;Marjo CE;Clode PL;Guagliardo P;Pickford R;Pernice M;Seymour JR;Raina JB, 2018, 'Quantifying inorganic nitrogen assimilation by synechococcus using bulk and single-cell mass spectrometry: A comparative study', Frontiers in Microbiology, vol. 9, http://dx.doi.org/10.3389/fmicb.2018.02847
Cullen A;D'Agostino PM;Mazmouz R;Pickford R;Wood S;Neilan BA, 2018, 'Insertions within the Saxitoxin Biosynthetic Gene Cluster Result in Differential Toxin Profiles', ACS chemical biology, vol. 13, pp. 3107 - 3114, http://dx.doi.org/10.1021/acschembio.8b00608
Kim WS;Jary E;Pickford R;He Y;Ahmed RM;Piguet O;Hodges JR;Halliday GM, 2018, 'Lipidomics analysis of behavioral variant frontotemporal dementia: A scope for biomarker development', Frontiers in Neurology, vol. 9, http://dx.doi.org/10.3389/fneur.2018.00104
von Jonquieres G;Spencer ZH T;Rowlands BD;Klugmann CB;Bongers A;Harasta AE;Parley KE;Cederholm J;Teahan O;Pickford R;Delerue F;Ittner LM;Fröhlich D;McLean CA;Don AS;Schneider M;Housley GD;Rae CD;Klugmann M, 2018, 'Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy', Acta Neuropathologica, vol. 135, pp. 95 - 113, http://dx.doi.org/10.1007/s00401-017-1784-9
Iborra RT;Machado-Lima A;Okuda LS;Pinto PR;Nakandakare ER;Machado UF;Correa-Giannella ML;Pickford R;Woods T;Brimble MA;Rye KA;Lu R;Yokoyama S;Passarelli M, 2018, 'AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages', Journal of Diabetes and its Complications, vol. 32, pp. 1 - 10, http://dx.doi.org/10.1016/j.jdiacomp.2017.09.012
da Silva KS;Pinto PR;Fabre NT;Gomes DJ;Thieme K;Okuda LS;Iborra RT;Freitas VG;Shimizu MH M;Teodoro WR;Marie SK N;Woods T;Brimble MA;Pickford R;Rye KA;Okamoto M;Catanozi S;Correa-Giannela ML;Machado UF;Passarelli M, 2017, 'N-acetylcysteine counteracts adipose tissue macrophage infiltration and insulin resistance elicited by advanced glycated albumin in healthy rats', Frontiers in Physiology, vol. 8, http://dx.doi.org/10.3389/fphys.2017.00723
Vishnumohan S;Pickford R;Arcot J, 2017, 'Naturally occurring folates in selected traditionally prepared foods in Southern India', Journal of Food Science and Technology, vol. 54, pp. 4173 - 4180, http://dx.doi.org/10.1007/s13197-017-2870-7
Liu T;Mazmouz R;Ongley SE;Chau R;Pickford R;Woodhouse JN;Neilan BA, 2017, 'Directing the Heterologous Production of Specific Cyanobacterial Toxin Variants', ACS Chemical Biology, vol. 12, pp. 2021 - 2029, http://dx.doi.org/10.1021/acschembio.7b00181
Pereyra JP A;D'Agostino PM;Mazmouz R;Woodhouse JN;Pickford R;Jameson I;Neilan BA, 2017, 'Molecular and morphological survey of saxitoxin-producing cyanobacterium Dolichospermum circinale (Anabaena circinalis) isolated from geographically distinct regions of Australia', Toxicon, vol. 138, pp. 68 - 77, http://dx.doi.org/10.1016/j.toxicon.2017.08.006
Wong MW;Braidy N;Poljak A;Pickford R;Thambisetty M;Sachdev PS, 2017, 'Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers', Alzheimer's and Dementia, vol. 13, pp. 810 - 827, http://dx.doi.org/10.1016/j.jalz.2017.01.008
Katoch M;Mazmouz R;Chau R;Pearson LA;Pickford R;Neilan BA, 2016, 'Heterologous production of cyanobacterial mycosporine-like amino acids mycosporine-ornithine and mycosporine-lysine in Escherichia coli', Applied and Environmental Microbiology, vol. 82, pp. 6167 - 6173, http://dx.doi.org/10.1128/AEM.01632-16
D'Agostino PM;Javalkote VS;Mazmouz R;Pickford R;Puranik PR;Neilan BA, 2016, 'Comparative profiling and discovery of novel glycosylated mycosporine-like amino acids in two strains of the cyanobacterium Scytonema cf. crispum', Applied and Environmental Microbiology, vol. 82, pp. 5951 - 5959, http://dx.doi.org/10.1128/AEM.01633-16
Kaakoush NO;Pickford R;Jaffe A;Ooi CY, 2016, 'Is there a role for stool metabolomics in cystic fibrosis?', Pediatrics International, vol. 58, pp. 808 - 811, http://dx.doi.org/10.1111/ped.13063
Hart-Smith G;Yagoub D;Tay AP;Pickford R;Wilkins MR, 2016, 'Large scale mass spectrometry-based identifications of enzyme-mediated protein methylation are subject to high false discovery rates', Molecular and Cellular Proteomics, vol. 15, pp. 989 - 1006, http://dx.doi.org/10.1074/mcp.M115.055384
Kashem MA;Ahmed S;Sultana N;Ahmed EU;Pickford R;Rae C;Šerý O;McGregor IS;Balcar VJ, 2016, 'Metabolomics of neurotransmitters and related metabolites in post-mortem tissue from the dorsal and ventral striatum of alcoholic human brain', Neurochemical Research, vol. 41, pp. 385 - 397, http://dx.doi.org/10.1007/s11064-016-1830-3
Richards SL;Cawley AT;Cavicchioli R;Suann CJ;Pickford R;Raftery MJ, 2016, 'Aptamer based peptide enrichment for quantitative analysis of gonadotropin-releasing hormone by LC-MS/MS', Talanta, vol. 150, pp. 671 - 680, http://dx.doi.org/10.1016/j.talanta.2016.01.006
Gomes DJ;Velosa AP;Okuda LS;Fusco FB;da Silva KS;Pinto PR;Nakandakare ER;Correa-Giannella ML;Woods T;Brimble MA;Pickford R;Rye KA;Teodoro WR;Catanozi S;Passarelli M, 2016, 'Glycated albumin induces lipid infiltration in mice aorta independently of DM and RAS local modulation by inducing lipid peroxidation and inflammation', Journal of Diabetes and its Complications, vol. 30, pp. 1614 - 1621, http://dx.doi.org/10.1016/j.jdiacomp.2016.07.001
Toscan CE;Rahimi M;Bhadbhade M;Pickford R;McAlpine SR;Lock RB, 2015, 'Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts', Organic and Biomolecular Chemistry, vol. 13, pp. 6299 - 6312, http://dx.doi.org/10.1039/c5ob00779h
Yau YY;Leong RW L;Shin S;Bustamante S;Pickford R;Hejazi L;Campbell B;Wasinger VC, 2014, 'Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases', Discovery Medicine, vol. 18, pp. 113 - 124
Couttas TA;Kain N;Daniels B;Lim XY;Shepherd C;Kril J;Pickford R;Li H;Garner B;Don AS, 2014, 'Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis', Acta Neuropathologica Communications, vol. 2, http://dx.doi.org/10.1186/2051-5960-2-9
Liu J;Pickford R;Meagher AP;Ward RL, 2011, 'Quantitative analysis of tissue folate using ultra high-performance liquid chromatography tandem mass spectrometry', Analytical Biochemistry, vol. 411, pp. 210 - 217, http://dx.doi.org/10.1016/j.ab.2010.12.033
dos Remedios CG;Estigoy C;Cameron D;Ho JW K;Herbert B;Padula M;Pickford R;Guilhaus M;Odeberg J;Ponten F, 2010, 'Proteomics of the Human Cardiac Intercalated Disc: A More Complex Multi-Functional Structure than was Previously Thought', BIOPHYSICAL JOURNAL, vol. 98, pp. 755A - 756A, http://dx.doi.org/10.1016/j.bpj.2009.12.4148
Bustamante S;Pickford R;Shin S;Luber R;Campbell B;Redmond D;Yau Y;Leong RW L;Wasinger V, 2010, 'Metabolomics in inflammatory bowel disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 25, pp. A83 - A83, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200226&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Kellmann R;Mihali TK;Young JJ;Pickford R;Pomati F;Neilan BA, 2008, 'Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria', Applied and Environmental Microbiology, vol. 74, pp. 4044 - 4053, http://dx.doi.org/10.1128/AEM.00353-08
Gruendling T;Pickford R;Guilhaus M;Barner-Kowollik C, 2008, 'Degradation of RAFT polymers in a cyclic ether studied via high resolution ESI-MS: Implications for synthesis, storage, and end-group modification', Journal of Polymer Science, Part A: Polymer Chemistry, vol. 46, pp. 7447 - 7461, http://dx.doi.org/10.1002/pola.23050
Rodrigues JA;Taylor AM;Sumpton DP;Reynolds JC;Pickford R;Thomas-Oates J, 2007, 'Mass Spectrometry of Carbohydrates: Newer Aspects', Advances in Carbohydrate Chemistry and Biochemistry, vol. 61, pp. 59 - 141, http://dx.doi.org/10.1016/S0065-2318(07)61003-8
Fedorow H;Pickford R;Kettle E;Cartwright M;Halliday GM;Gerlach M;Riederer P;Garner B;Double KL, 2006, 'Investigation of the lipid component of neuromelanin', Journal of Neural Transmission, vol. 113, pp. 735 - 739, http://dx.doi.org/10.1007/s00702-006-0451-4
Fedorow H;Pickford R;Hook JM;Double KL;Halliday GM;Gerlach M;Riederer P;Garner B, 2005, 'Dolichol is the major lipid component of human substantia nigra neuromelanin', Journal of Neurochemistry, vol. 92, pp. 990 - 995, http://dx.doi.org/10.1111/j.1471-4159.2004.02975.x
White IR;Pickford R;Wood J;Skehel JM;Gangadharan B;Cutler P, 2004, 'A statistical comparison of silver and SYPRO Ruby staining for proteomic analysis', Electrophoresis, vol. 25, pp. 3048 - 3054, http://dx.doi.org/10.1002/elps.200405947
Kuiper I;Lagendijk EL;Pickford R;Derrick JP;Lamers GE M;Thomas-Oates JE;Lugtenberg BJ J;Bloemberg GV, 2004, 'Characterization of two Pseudomonas putida lipopeptide biosurfactants, putisolvin I and II, which inhibit biofilm formation and break down existing biofilms', Molecular Microbiology, vol. 51, pp. 97 - 113, http://dx.doi.org/10.1046/j.1365-2958.2003.03751.x
Hansen HR;Pickford R;Thomas-Oates J;Jaspars M;Feldmann J, 2004, '2-Dimethylarsinothioyl Acetic Acid Identified in a Biological Sample: The First Occurrence of a Mammalian Arsinothioyl Metabolite', Angewandte Chemie - International Edition, vol. 43, pp. 337 - 340, http://dx.doi.org/10.1002/anie.200352740
Miguens-Rodriguez M;Pickford R;Thomas-Oates JE;Pergantis SA, 2002, 'Arsenosugar identification in seaweed extracts using high-performance liquid chromatography/electrospray ion trap mass spectrometry', Rapid Communications in Mass Spectrometry, vol. 16, pp. 323 - 331, http://dx.doi.org/10.1002/rcm.578
Pickford R;Miguens-Rodriguez M;Afzaal S;Speir P;Pergantis SA;Thomas-Oates JE, 2002, 'Application of the high mass accuracy capabilities of FT-ICR-MS and Q-ToF-MS to the characterisation of arsenic compounds in complex biological matrices', Journal of Analytical Atomic Spectrometry, vol. 17, pp. 173 - 176, http://dx.doi.org/10.1039/b109842j
Cutler P;Bell DJ;Birrell HC;Connelly JC;Connor SC;Holmes E;Mitchell BC;Monté SY;Neville BA;Pickford R;Polley S;Schneider K;Skehel JM, 1999, 'An integrated proteomic approach to studying glomerular nephrotoxicity', Electrophoresis, vol. 20, pp. 3647 - 3658, http://dx.doi.org/10.1002/(SICI)1522-2683(19991201)20:18<3647::AID-ELPS3647>3.0.CO;2-#
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Location

Rm B49, Basement, Chemical Sciences Bldg (F10)

Contact

+61 (2) 9385 2952
+61 (2) 9385 5473