Dr Valerie Wasinger

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Senior Research Scientist

Category: Academic Staff
Research profile: Click to view

Biography

Dr Wasinger's research focuses on the advancement of analytical techniques fostering accurate and sensitive measurement of peptides and proteins within the context of mass spectrometry based analysis of the proteome and metabolome. She has a background in microbiology and is keenly interested in improving detection of low mass, endogenous proteins and peptides and translating this into tangible methods to deepen understanding of biological processes. Her research focuses on a variety of medical diseases with over 10 years' experience in developing biotech and proteomic solutions for IBD and cancer, as well as methodologies for forensic and paleoproteomic and bioarchaeological research.

Dr Wasinger is recognised in the field of proteomics, most notably, as the first author on the foundation paper describing the term ‘proteomics’. This work was a collaboration between Sydney, NSW and Macquarie Universities. It was this paper that was the very first to define proteomics and apply this field of research to a model organism- Mycoplasma genitalium (Wasinger et. al. 1995). As described in the publication; the field uses a combination of techniques, and Wasinger’s research has always centred on expanding the boundaries through complementary methods to characterise the proteome. This work has been built on with continued research in: the first ‘complete’ proteome available for life at its most basic: M.genitalium (Wasinger et.al 2000); the international effort and first publication of the human plasma proteome (Omenn et al., 2005, Wasinger et al., 2005).

Her recent work has led to two patents in the IBD sphere. She has expertise in the translation of discovery research into clinically useful products; experience in the application of  life science ‘-omics’ technologies; partnerships, collaborations, project management, licensing and commercialisation. Collaborating groups range from national and international universities as well as medical institutes. Dr Wasinger has supervised numerous PhD candidates, Honours and Masters, as well as ILP medical students.

Publications

Book Chapters

Ping P; Vondriska TM; Creighton CJ; Gandhi TKB; Yang Z; Menon R; Kwon MS; Cho SY; Drwal G; Kellmann M; Peri S; Suresh S; Gronborg M; Molina H; Chaerkady R; Rekha B; Shet AS; Gerszten RE; Wu H; Raftery M; Wasinger V; Schulz-Knappe P; Hanash SM; Paik YK; Hancock WS; States DJ; Omenn GS; Pandey A, 2006, 'A functional annotation of subproteomes in human plasma', in Exploring the Human Plasma Proteome, pp. 329 - 351, http://dx.doi.org/10.1002/9783527609482.ch16
Omenn GS; States DJ; Adamski M; Blackwell TW; Menon R; Hermjakob H; Apweiler R; Haab BB; Simpson RJ; Eddes JS; Kapp EA; Moritz RL; Chan DW; Rai AJ; Admon A; Aebersold R; Eng J; Hancock WS; Hefta SA; Meyer H; Paik YK; Yoo JS; Ping P; Pounds J; Adkins J; Qian X; Wang R; Wasinger V; Wu CY; Zhao X; Zeng R; Archakov A; Tsugita A; Beer I; Pandey A; Pisano M; Andrews P; Tammen H; Speicher DW; Hanash SM, 2006, 'Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database', in Exploring the Human Plasma Proteome, pp. 1 - 35, http://dx.doi.org/10.1002/9783527609482.ch1
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Wasinger VC, 2006, 'Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics', in Microbial Proteomics - Functional Biology of Whole Organisms, Wiley-Liss, USA, pp. 1 - 14
Wasinger V, 2005, 'Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics', in Microbial Proteomics: Functional Biology of Whole Organisms, pp. 3 - 14, http://dx.doi.org/10.1002/0471973165.ch1

Conference Abstracts

Tavakoli P; Wu N; Shapiro AJ; Sanchez-Lomba B; Pipicella JL; Lo L; Williams A-J; Ghaly S; Leach ST; Corte C; Burke C; Samocha-Bonet D; Lambert K; Wasinger V; Dutt S; Pavli P; Grimm MC; Lemberg D; Connor S; Leong R; Hold G; Paramsothy R; O'Brien C, 2022, 'A snapshot of inflammatory bowel disease in Australia: Interim analysis of the Australian IBD Microbiome (AIM) Study cohort', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 37, pp. 159 - 159, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852585700240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Hao J; Graham PH; Chang L; Ni J; Wasinger V; Beretov J; Bucci J; Cozzi P; Li Y, 2015, 'Identification of lactate dehydrogenase A (LDHA) as a potential therapeutic target for prostate cancer radiotherapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 75, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-2001

Conference Papers

Trist B; Davies K; Cottam V; Genoud S; Ortega R; Roudeau S; Carmona A; Silva KD; Wasinger V; Halliday G; Hare D; Double K, 2017, 'Novel superoxide dismutase-1 proteinopathy is associated with Lewy pathology and neuronal loss in Parkinson's disease', in JOURNAL OF NEUROCHEMISTRY, WILEY, FRANCE, Paris, pp. 111 - 111, presented at ISN-ESN Meeting, FRANCE, Paris, 20 August 2017 - 24 August 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407425300238&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Yau Y; Leong RW; Wasinger VC, 2013, 'Increased Levels of Serum Fatty Acid Binding Protein 5 in Fistulizng Crohn's Disease Found by Novel Proteotypic Peptide Monitoring', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, FL, Orlando, pp. S623 - S623, presented at Digestive Disease Week / 28th Annual Residents and Fellows Research Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT), FL, Orlando, 18 May 2013 - 21 May 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322997203447&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Yau Y; Leong R; Wasinger VC, 2012, 'Enrichment of epithelial intermediate filament proteins in Crohn's disease sera associated with disease behaviour phenotype and disease activity', in Journal of Gastroenterology and Hepatology, Blackwell Publishing Asia, Carlton, Victoria, Australia, pp. 27 28-29; 4 SI OCT 2012, presented at Australian Gastroenterology Week 2012, Adelaide
Alkhouri H; Wasinger V; Moir LM; Armour CL; Hughes JM, 2011, 'Proteomic Identification Of Factors That Regulate Mast Cell Localization To The Airway Smooth Muscle Cells In Asthma', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208770303169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Goodchild A; Saunders NF; Wasinger VC, 2002, 'Understanding cold-adaptation of Methanococcoides burtonii using 2D-PAGE', in Takayama K (ed.), School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, Sydney, pp. 6 - 6, presented at School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, Sydney, 08 November 2002
Wasinger VC; Bjellqvist B; Humphery-Smith I, 1997, 'Proteomic 'contigs' of Ochrobacterium anthropi, application of extensive pH gradients', in Electrophoresis, pp. 1373 - 1383, http://dx.doi.org/10.1002/elps.1150180812

Conference Presentations

Yau Y; Leong RW; Puddipeddi A; Perananthan V; Redmond D; Chang J; Wasinger VC, 2014, 'Association of serological epithelial component proteins with complicated Crohn's disease by discovery and verification phase proteomics', Vol. 29, pp. 25 - 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
You J; Fitzgerald A; Schiller S; Cozzi PJ; Walsh B; Willcox MD; Wasinger VC; Li Y, 2010, 'Identification of potential biomarkers for prostate cancer in tears and serum using proteomic approaches', presented at The Inaugural Biomarker Discovery Conference, Port Stephens NSW Australia, 06 December 2010 - 10 December 2010
You J; Fitzgerald A; Cozzi PJ; Zhao Z; Graham PH; Russell PJ; Walsh B; Willcox MD; Wasinger VC; Li Y, 2010, 'Identification of potential biomarkers for prostate cancer in tears and serum using proteomic approaches', presented at HUPO-9th Annual World Congress, Sydney, Australia, 19 September 2010 - 23 September 2010

Journal articles

Manandhar B; Pandzic E; Deshpande N; Chen SY; Wasinger VC; Kockx M; Glaros EN; Ong KL; Thomas SR; Wilkins MR; Whan RM; Cochran BJ; Rye KA, 2024, 'ApoA-I Protects Pancreatic β-Cells from Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin', Arteriosclerosis, Thrombosis, and Vascular Biology, 44, pp. E20 - E38, http://dx.doi.org/10.1161/ATVBAHA.123.319378
Jenkins LC; Chang WJ; Humburg P; Wasinger VC; Stone LS; Dorsey SG; Renn C; Starkweather A; Schabrun SM, 2024, 'Sex Differences in the Serum Proteomic Profile During Acute Low Back Pain—A Preliminary Study of the Relationship to Future Low Back Pain', Journal of Pain, http://dx.doi.org/10.1016/j.jpain.2023.11.009
Yu J; Boland L; Catt M; Puk L; Wong N; Krockenberger M; Bennett P; Ruaux C; Wasinger VC, 2023, 'Serum proteome profiles in cats with chronic enteropathies', Journal of Veterinary Internal Medicine, 37, pp. 1358 - 1367, http://dx.doi.org/10.1111/jvim.16743
Lee Y; Ni J; Beretov J; Wasinger VC; Graham P; Li Y, 2023, 'Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis', Molecular Cancer, 22, http://dx.doi.org/10.1186/s12943-023-01741-x
Chang WJ; Jenkins LC; Humburg P; Wasinger V; Walton DM; Schabrun SM, 2023, 'Systemic pro- and anti-inflammatory profiles in acute non-specific low back pain: An exploratory longitudinal study of the relationship to six-month outcome', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0287192
Jenkins LC; Chang WJ; Buscemi V; Liston M; Nicholas M; Graven-Nielsen T; Hodges PW; Wasinger VC; Stone LS; Dorsey SG; McAuley JH; Schabrun SM, 2023, 'The Understanding Persistent Pain Where it ResiDes Study of Low Back Pain Cohort Profile', New Zealand Journal of Physiotherapy, 51, pp. 199 - 216, http://dx.doi.org/10.15619/nzjp.v51i3.375
Lee Y; Ni J; Wasinger VC; Graham P; Li Y, 2023, 'Comparison Study of Small Extracellular Vesicle Isolation Methods for Profiling Protein Biomarkers in Breast Cancer Liquid Biopsies', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms242015462
Yu J; Ruaux C; Griebsch C; Boland L; Wong N; Bennett P; Wasinger VC, 2023, 'Serum proteome of dogs with chronic enteropathy', Journal of Veterinary Internal Medicine, 37, pp. 925 - 935, http://dx.doi.org/10.1111/jvim.16682
Bustamante S; Yau Y; Boys V; Chang J; Paramsothy S; Pudipeddi A; Leong RW; Wasinger VC, 2022, 'Tryptophan Metabolism ‘Hub’ Gene Expression Associates with Increased Inflammation and Severe Disease Outcomes in COVID-19 Infection and Inflammatory Bowel Disease', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms232314776
Yau YY; Wasinger VC; Hirten RP; Chuang E; Huntsman M; Stylli J; Shimizu J; Yajnik V; Smith J; Lee SN; Singh S; Wahl C; Leong RW; Sands BE, 2021, 'Current trends in IBD - Development of mucosal-based biomarkers and a novel minimally invasive recoverable sampling system', Inflammatory Bowel Diseases, 27, pp. S17 - S24, http://dx.doi.org/10.1093/ibd/izab179
Bai X; Ni J; Beretov J; Wasinger VC; Wang S; Zhu Y; Graham P; Li Y, 2021, 'Activation of the eIF2 alpha/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis', REDOX BIOLOGY, 43, http://dx.doi.org/10.1016/j.redox.2021.101993
Bai X; Ni J; Beretov J; Wasinger VC; Wang S; Zhu Y; Graham P; Li Y, 2021, 'Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis', Redox Biology, 43, http://dx.doi.org/10.1016/j.redox.2021.101993
Williams AJ; Paramsothy R; Wu N; Ghaly S; Leach S; Paramsothy S; Corte C; O'Brien C; Burke C; Wark G; Samocha-Bonet D; Lambert K; Ahlenstiel G; Wasinger V; Dutt S; Pavli P; Grimm M; Lemberg D; Connor S; Leong R; Hold G, 2021, 'Australia IBD Microbiome (AIM) Study: Protocol for a multicentre longitudinal prospective cohort study', BMJ Open, 11, http://dx.doi.org/10.1136/bmjopen-2020-042493
Manandhar B; Pandzic E; Deshpande N; Chen S-Y; Wasinger VC; Kockx M; Glaros E; Ong KL; Thomas S; Wilkins M; Whan R; Cochran BJ; Rye KA, 2021, 'The Anti-Oxidant Function Of Apolipoprotein A-I Rescues Pancreatic beta-Cells From Cholesterol-Induced Mitochondrial Dysfunction', ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41, http://dx.doi.org/10.1161/atvb.41.suppl_1.122
Wasinger VC; Lu K; Yau YY; Nash J; Lee J; Chang J; Paramsothy S; Kaakoush NO; Mitchell HM; Leong RWL, 2020, 'Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-69746-w
Wasinger VC; Curnoe D; Boel C; Machin N; Goh HM, 2020, 'The Molecular Floodgates of Stress-Induced Senescence Reveal Translation, Signalling and Protein Activity Central to the Post-Mortem Proteome', International Journal of Molecular Sciences, 21, pp. 6422 - 6422, http://dx.doi.org/10.3390/ijms21176422
Feng X; Bai X; Ni J; Wasinger VC; Beretov J; Zhu Y; Graham P; Li Y, 2019, 'CHTOP in chemoresistant epithelial ovarian cancer: A novel and potential therapeutic target', Frontiers in Oncology, 9, http://dx.doi.org/10.3389/fonc.2019.00557
Wasinger VC; Curnoe D; Bustamante S; Mendoza R; Shoocongdej R; Adler L; Baker A; Chintakanon K; Boel C; Tacon PSC, 2019, 'Analysis of the Preserved Amino Acid Bias in Peptide Profiles of Iron Age Teeth from a Tropical Environment Enable Sexing of Individuals Using Amelogenin MRM', Proteomics, 19, http://dx.doi.org/10.1002/pmic.201800341
Leong RWL; Kaakoush NO; Yau YY; Wasinger VC, 2019, 'Editorial: metabolomic biomarkers for colorectal adenocarcinoma and in the differentiation between irritable bowel syndrome and ulcerative colitis in clinical remission— confounded by the gut microbiome?', Alimentary Pharmacology and Therapeutics, 49, pp. 1086 - 1087, http://dx.doi.org/10.1111/apt.15171
Lee JY; Wasinger VC; Yau YY; Chuang E; Yajnik V; Leong RWL, 2018, 'Molecular pathophysiology of epithelial barrier dysfunction in inflammatory bowel diseases', Proteomes, 6, http://dx.doi.org/10.3390/PROTEOMES6020017
Chang J; Leong RW; Wasinger VC; Ip M; Yang M; Phan TG, 2017, 'Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing', Gastroenterology, 153, pp. 723 - 731.e1, http://dx.doi.org/10.1053/j.gastro.2017.05.056
Wu D; Ni J; Beretov J; Cozzi P; Willcox M; Wasinger V; Walsh B; Graham P; Li Y, 2017, 'Urinary biomarkers in prostate cancer detection and monitoring progression', Critical Reviews in Oncology/Hematology, 118, pp. 15 - 26, http://dx.doi.org/10.1016/j.critrevonc.2017.08.002
Chang L; Ni J; Beretov J; Wasinger VC; Hao J; Bucci J; Malouf D; Gillatt D; Graham PH; Li Y, 2017, 'Identification of protein biomarkers and signaling pathways associated with prostate cancer radioresistance using label-free LC-MS/MS proteomic approach', Scientific Reports, 7, http://dx.doi.org/10.1038/srep41834
Yau YY; Leong RWL; Pudipeddi A; Redmond D; Wasinger VC, 2017, 'Serological epithelial component proteins identify intestinal complications in Crohn's disease', Molecular and Cellular Proteomics, 16, pp. 1244 - 1257, http://dx.doi.org/10.1074/mcp.M116.066506
Trist BG; Davies KM; Cottam V; Genoud S; Ortega R; Roudeau S; Carmona A; De Silva K; Wasinger V; Lewis SJG; Sachdev PS; Smith B; Troakes C; Vance C; Shaw C; Al-Sarraj S; Ball HJ; Halliday GM; Hare DJ; Double KL, 2017, 'Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain', Acta Neuropathologica, http://dx.doi.org/10.1007/s00401-017-1726-6
Mourad FH; Yau Y; Wasinger VC; Leong RW, 2017, 'Proteomics in Inflammatory Bowel Disease: Approach Using Animal Models', Digestive Diseases and Sciences, 62, pp. 2266 - 2276, http://dx.doi.org/10.1007/s10620-017-4673-0
Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P; Patel M; Ryder WJ; Bongers A; Maraninchi M; Wasinger VC; Westerterp M; Tall AR; Barter PJ; Rye K-A, 2017, 'Impact of Perturbed Pancreatic beta-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism (vol 65, pg 3610, 2016)', DIABETES, 66, pp. 560 - 560, http://dx.doi.org/10.2337/db17-er02b
Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P; Patel M; Ryder WJ; Bongers A; Maraninchi M; Wasinger VC; Westerterp M; Tall AR; Barter PJ; Rye KA, 2016, 'Impact of perturbed pancreatic β-cell cholesterol homeostasis on adipose tissue and skeletal muscle metabolism', Diabetes, 65, pp. 3610 - 3620, http://dx.doi.org/10.2337/db16-0668
Hao J; Graham P; Chang L; Ni J; Wasinger V; Beretov J; Deng J; Duan W; Bucci J; Malouf D; Gillatt D; Li Y, 2016, 'Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy', Oncotarget, 7, pp. 74269 - 74285, http://dx.doi.org/10.18632/oncotarget.12368
You J; Willcox M; Fitzgerald A; Schiller B; Cozzi PJ; Russell PJ; Walsh BJ; Wasinger VC; Graham PH; Li Y, 2016, 'Absolute quantification of human tear lactoferrin using multiple reaction monitoring technique with stable-isotopic labeling', Analytical Biochemistry, 496, pp. 30 - 34, http://dx.doi.org/10.1016/j.ab.2015.12.006
Chan PP; Wasinger VC; Leong RW, 2016, 'Current application of proteomics in biomarker discovery for inflammatory bowel disease.', World J Gastrointest Pathophysiol, 7, pp. 27 - 37, http://dx.doi.org/10.4291/wjgp.v7.i1.27
Wasinger VC; Yau Y; Duo X; Zeng M; Campbell B; Shin S; Luber R; Redmond D; Leong RWL, 2016, 'Low mass blood peptides discriminative of inflammatory bowel disease (IBD) severity: A quantitative proteomic perspective', Molecular and Cellular Proteomics, 15, pp. 256 - 265, http://dx.doi.org/10.1074/mcp.M115.055095
Deng J; Wang L; Ni J; Beretov J; Wasinger V; Wu D; Duan W; Graham P; Li Y, 2016, 'Proteomics discovery of chemoresistant biomarkers for ovarian cancer therapy', Expert Review of Proteomics, http://dx.doi.org/10.1080/14789450.2016.1233065
Yau YY; Duo X; Leong RWL; Wasinger VC, 2015, 'Reverse-polynomial dilution calibration methodology extends lower limit of quantification and reduces relative residual error in targeted peptide measurements in blood plasma', Molecular and Cellular Proteomics, 14, pp. 441 - 454, http://dx.doi.org/10.1074/mcp.M114.040790
Beretov J; Wasinger VC; Millar EKA; Schwartz P; Graham PH; Li Y, 2015, 'Proteomic analysis of urine to identify breast cancer biomarker candidates using a label-free LC-MS/MS approach', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0141876
Beretov J; Wasinger VC; Graham PH; Millar EK; Kearsley JH; Li Y, 2014, 'Proteomics for breast cancer urine biomarkers', , 63, pp. 123 - 167, http://dx.doi.org/10.1016/B978-0-12-800094-6.00004-2
Kim PY; Tan O; Diakiw SM; Carter D; Sekerye EO; Wasinger VC; Liu T; Kavallaris M; Norris MD; Haber M; Chesler L; Dolnikov A; Trahair TN; Cheung NK; Marshall GM; Cheung BB, 2014, 'Identification of plasma Complement C3 as a potential biomarker for neuroblastoma using a quantitative proteomic approach', Journal of Proteomics, 96, pp. 1 - 12, http://dx.doi.org/10.1016/j.jprot.2013.10.032
Coumans JVF; Gau D; Poljak A; Wasinger V; Roy P; Moens PDJ, 2014, 'Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses', OMICS A Journal of Integrative Biology, 18, pp. 778 - 791, http://dx.doi.org/10.1089/omi.2014.0075
Frölich S; Shahparee A; Wasinger VC; Wallach M, 2014, 'In vivo localization of antibodies raised against Eimeria maxima wall forming bodies during sexual intracellular development', Parasitology, 141, pp. 1726 - 1735, http://dx.doi.org/10.1017/S0031182014001012
Yau YY; Leong RWL; Shin S; Bustamante S; Pickford R; Hejazi L; Campbell B; Wasinger VC, 2014, 'Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases', Discovery Medicine, 18, pp. 113 - 124
Beretov J; Wasinger VC; Schwartz P; Graham PH; Li Y, 2014, 'A Standardized and Reproducible Urine Preparation Protocol for Cancer Biomarkers Discovery', Biomarkers in Cancer, 6, pp. bic.s17991 - bic.s17991, http://dx.doi.org/10.4137/bic.s17991
Coumans JVF; Gau D; Poljak A; Wasinger V; Roy P; Moens P, 2014, 'Green fluorescent protein expression triggers proteome changes in breast cancer cells', Experimental Cell Research, 320, pp. 33 - 45, http://dx.doi.org/10.1016/j.yexcr.2013.07.019
Lei C; Wasinger V; Graham P; Hao J; Ni J; Beretov J; Bucci J; Cozzi P; Kearsley J; Li Y, 2014, 'THE USE OF LABEL-FREE LC-MS/MS APPROACH TO IDENTIFY SIGNALING PATHWAYS ASSOCIATED WITH PROSTATE CANCER RADIORESISTANCE', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 10, pp. 130 - 130, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345350900164&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
You J; Willcox MD; Madigan MC; Wasinger V; Schiller B; Walsh BJ; Graham PH; Kearsley JH; Li Y, 2013, 'Tear Fluid Protein Biomarkers', , 62, pp. 151 - 196, http://dx.doi.org/10.1016/B978-0-12-800096-0.00004-4
Cruciani F; Wasinger V; Turroni S; Calanni F; Donders G; Brigidi P; Vitali B, 2013, 'Proteome profiles of vaginal fluids from women affected by bacterial vaginosis and healthy controls: Outcomes of rifaximin treatment', Journal of Antimicrobial Chemotherapy, 68, pp. 2648 - 2659, http://dx.doi.org/10.1093/jac/dkt244
Lee THY; Mitchell A; Lau SL; An H; Rajeaskariah P; Wasinger V; Raftery M; Bryant K; Tedla N, 2013, 'Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein', Journal of Biological Chemistry, 288, pp. 32873 - 32885, http://dx.doi.org/10.1074/jbc.M113.478578
Yau Y; Leong RW; Zeng M; Wasinger VC, 2013, 'Proteomics and metabolomics in inflammatory bowel disease', Journal of Gastroenterology and Hepatology (Australia), 28, pp. 1076 - 1086, http://dx.doi.org/10.1111/jgh.12193
Wasinger VC; Zeng M; Yau Y, 2013, 'Current status and advances in quantitative proteomic mass spectrometry.', Int J Proteomics, 2013, pp. 180605, http://dx.doi.org/10.1155/2013/180605
Balasubramanian SA; Wasinger VC; Pye DC; Willcox MDP, 2013, 'Preliminary identifcation of differentially expressed tear proteins in keratoconus', Molecular Vision, 19, pp. 2124 - 2134
Norazman N; Wu W; Li H; Wasinger V; Zhang H; Chen V, 2013, 'Evaluation of chemical cleaning of UF membranes fouled with whey protein isolates via analysis of residual protein components on membranes surface', Separation and Purification Technology, 103, pp. 241 - 250, http://dx.doi.org/10.1016/j.seppur.2012.10.039
Yau Y; Leong RW; Wasinger VC, 2013, 'Mo1269 Increased Levels of Serum Fatty Acid Binding Protein 5 in Fistulizng Crohn's Disease Found by Novel Proteotypic Peptide Monitoring', Gastroenterology, 144, pp. S - 623, http://dx.doi.org/10.1016/s0016-5085(13)62302-1
Wang M; Han B; Wasinger V, 2013, 'Advances in quantitative mass spectrometry.', Int J Proteomics, 2013, pp. 621029, http://dx.doi.org/10.1155/2013/621029
Yau Y; Leong RW; Wasinger VC, 2012, 'Enrichment of epithelial intermediate filament proteins in Crohn's disease sera associated with disease behaviour phenotype and disease activity', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 27, pp. 28 - 29, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308642600061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Ly L; Wasinger VC, 2011, 'Protein and peptide fractionation, enrichment and depletion: tools for the complex proteome', Proteomics, 11, pp. 513 - 534
Yau Y; Shin SS; Bustamante S; Pickford R; Leong RW; Wasinger VC, 2011, 'Tryptophan Metabolome Signature Differences in Inflammatory Bowel Diseases', Gastroenterology, 140, pp. S - 840, http://dx.doi.org/10.1016/s0016-5085(11)63487-2
Zhao Z; Liu J; Wasinger VC; Malouf T; Nguyen-Khuong T; Walsh B; Willcox MD, 2010, 'Tear lipocalin is the predominant phosphoprotein in human tear fluid', Experimental Eye Research, 90, pp. 344 - 349
Ly L; Wasinger VC, 2010, 'Mass and charge selective protein fractionation for the differential analysis of T-cell and CD34+ stem cell proteins from cord blood', Journal of Proteomics, 73, pp. 571 - 578
Bustamante S; Pickford R; Shin S; Luber R; Campbell B; Redmond D; Yau Y; Leong RWL; Wasinger V, 2010, 'Metabolomics in inflammatory bowel disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 25, pp. A83 - A83, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200226&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
You J; Fitzgerald A; Cozzi PJ; Zhao Z; Graham P; Russell PJ; Walsh BJ; Willcox M; Zhong L; Wasinger V; Li Y, 2010, 'Post‐translation modification of proteins in tears', PROTEOMICS – Clinical Applications, 4, pp. 870 - 870, http://dx.doi.org/10.1002/prca.201090087
Ly L; Wasinger VC, 2008, 'Peptide enrichment and protein fractionation using selective electrophoresis', Proteomics, 8, pp. 4197 - 4208
Wasinger VC; Ly L; Fitzgerald A; Walsh B, 2008, 'Prefractionation, Enrichment, Desalting and Depleting of Low Volume and Low Abundance Proteins and Peptides Using the MF10', Methods in Molecular Biology, Two Dimensional Electrophoresis Protocols, 424, pp. 257 - 275
Vitali B; Turroni S; Dal Piaz F; Candela M; Wasinger VC; Brigidi P, 2007, 'Genetic and proteomic characterization of rifaximin resistance in Bifidobacterium infantis BI07', Research in Microbiology, 158, pp. 355 - 362
McCann L; Haywood M; Ren B; Simpson AM; Guilhaus M; Wasinger VC; Raftery MJ; Davey R, 2007, 'Identification of Vascular Surface Proteins by in Vivo Biotinylation: A Method Sufficiently Sensitive To Detect Changes in Rat Liver 2 Weeks After Partial Hepatectomy', Journal of Proteome Research, 6, pp. 3108 - 3113
Corthals GL; Wasinger VC; Goodlett DR, 2007, 'Offline Micro-IMAC Enrichment of Phosphoproteins.', CSH Protoc, 2007, pp. pdb.prot4624, http://dx.doi.org/10.1101/pdb.prot4624
Corthals GL; Wasinger VC; Goodlett DR, 2007, 'Analysis of Phosphopeptides by {micro}LC-ESI-MS/MS.', CSH Protoc, 2007, pp. pdb.prot4625, http://dx.doi.org/10.1101/pdb.prot4625
Wasinger V, 2006, 'Holistic biology of microorganisms: Genomics, transcriptomics, and proteomics', Methods of Biochemical Analysis, 49, pp. 3 - 14
Omenn G; States D; Adamski M; Blackwell T; Menon R; Hermjakob H; Apweiler R; Haab B; Simpson R; Eddes J; Kapp E; Moritz R; Chan DJ; Rai A; Admon A; Aebersold R; Eng JJ; Hancock W; Hefta S; Meyer H; Paik Y; Yoo J; Ping P; Pounds J; Adkins J; Qian X; Wang R; Wasinger VC; Wu C; Zhao X; Zeng R; Archakov A; Tsugita A; Beer I; Pandey A; Pisano M; Andrews PJ; Tammen H; Speicher D; Hanash S, 2005, 'Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database', Proteomics, 5, pp. 3226 - 3245
Larance MC; Ramm GA; Stockli J; Van Dam EM; Winata SC; Wasinger VC; Simpson F; Graham M; Junutula J; Guilhaus M; James DE, 2005, 'Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking', The Journal of Biological Chemistry, 280, pp. 37803 - 37813
Vitali B; Wasinger VC; Brigidi P; Guilhaus M, 2005, 'A proteomic view of Bifidobacterium infantis generated by multi-dimensional chromatography coupled with tandem mass spectrometry', Proteomics, 5, pp. 1859 - 1867
Ping P; Vondriska T; Creighton C; Gandhi T; Yang Z; Menon R; Kwon M; Cho S; Drwal G; Kellmann M; Peri S; Suresh S; Gronborg M; Molina H; Chaerkady R; Rekha B; Shet A; Gerszten R; Wu H; Raftery MJ; Wasinger VC; Schulz-Knappe P; Hanash S; Paik Y; Hancock W; States D; Omenn G; Pandey A, 2005, 'A functional annotation of subproteomes in human plasma', Proteomics, 5, pp. 3506 - 3519
Larance MC; Klopcic B; Wasinger VC, 2005, 'Proteomics: An overview', Inflammatory Bowel Diseases, 11, pp. 927 - 936
Wasinger VC; Locke VL; Raftery MJ; Larance MC; Rothemund DL; Liew A; Bate I; Guilhaus M, 2005, 'Two-dimensional liquid chromatography/tandem mass spectrometry analysis of Gradiflow (TM) fractionated native human plasma', Proteomics, 5, pp. 3397 - 3401
Burchfield JG; Lennard A; Narasimhan S; Hughes WE; Wasinger VC; Corthals GL; Okuda T; Kondoh H; Biden TJ; Schmitz-Peiffer et A, 2004, 'Akt Mediates Insulin-stimulated Phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C θ', The Journal of Biological Chemistry, 279, pp. 18623 - 18632, http://www.sciencedirect.com/science/article/B6WPV-4CJT94G-2YX/2/8e96d5728ca79a495aa6ff34cc71ecc2
Ostrowski ML; Fegatella F; Wasinger VC; Guilhaus M; Corthals GL; Cavicchioli R, 2004, 'Cross-species identification of proteins from proteome profiles of the marine oligotrophic ultramicrobacterium, Sphingopyxis alaskensis', Proteomics, 4, pp. 1779 - 1788
Diaz P; Zilm P; Wasinger VC; Corthals GL; Rogers A, 2004, 'Studies on NADH oxidase and alkyl hydroperoxide reductase produced byPorphyromonas gingivalis', Oral Microbiology and Immunology, 19, pp. 137 - 143
Henness S; Davey M; Harvie R; Banyer J; Wasinger VC; Corthals GL; Davey R, 2004, 'Changes in gene expression associated with stable drug and radiationresistance in small cell lung cancer cells are similar to those causedby a single X-ray dose', Radiation Research, 161, pp. 495 - 503
Lynch DK; Winata SC; Lyons RJ; Hughes WE; Lehrbach GM; Wasinger VC; Corthals GL; Cordwell SJ; Daly RJ, 2003, 'A cortactin/CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton', The Journal of Biological Chemistry, 278, pp. 21805 - 21813
Rothemund DL; Locke VL; Liew A; Thomas TM; Wasinger VC; Rylatt DB, 2003, 'Depletion of the highly abundant protein albumin from human plasma using the Gradiflow', Proteomics, 31, pp. 279 - 287
Wasinger VC; Corthals GL, 2002, 'Proteomic tools for biomedicine', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 771, pp. 33 - 48, http://dx.doi.org/10.1016/S1570-0232(02)00125-3
Wasinger VC; Dennis Pollack J; Humphery-Smith I, 2000, 'The proteome of Mycoplasma genitalium: Chaps-soluble component', European Journal of Biochemistry, 267, pp. 1571 - 1582, http://dx.doi.org/10.1046/j.1432-1327.2000.01183.x
Corthals CL; Wasinger VC; Hochstrasser DF; Sanchez JC, 2000, 'The dynamic range of protein expression: A challenge for proteomic research', Electrophoresis, 21, pp. 1104 - 1115, http://dx.doi.org/10.1002/(SICI)1522-2683(20000401)21:6<1104::AID-ELPS1104>3.0.CO;2-C
Wasinger VC; Urquhart BL; Humphery-Smith I, 1999, 'Cross-species characterisation of abundantly expressed Ochrobactrum anthropi gene products', Electrophoresis, 20, pp. 2196 - 2203, http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2196::AID-ELPS2196>3.0.CO;2-V
Wasinger V, 1998, 'Small genes/gene-products in Escherichia coli K-12', FEMS Microbiology Letters, 169, pp. 375 - 382, http://dx.doi.org/10.1016/s0378-1097(98)00507-2
Rudd KE; Humphery-Smith I; Wasinger VC; Bairoch A, 1998, 'Low molecular weight proteins: A challenge for post-genomic research', Electrophoresis, 19, pp. 536 - 544, http://dx.doi.org/10.1002/elps.1150190413
Wasinger VC; Humphery-Smith I, 1998, 'Small genes/gene-products in Escherichia coli K-12', FEMS Microbiology Letters, 169, pp. 375 - 382, http://dx.doi.org/10.1016/S0378-1097(98)00507-2
Cordwell SJ; Wasinger VC; Poljak A; Duncan MW; Humphery-Smith I, 1997, 'Conserved motifs as the basis for recognition of homologous proteins across species boundaries using peptide-mass fingerprinting', Journal of Mass Spectrometry, pp. 370 - 380
Wasinger VC; Cordwell SJ; Poljak A; Yan JX; Gooley AA; Wilkins MR; Duncan MW; Harris RI; Williams KM; Humphery-Smith I, 1995, 'Progress with gene-product mapping of the mollicutes: mycroplasma genitalium', Electrophoresis, 16, pp. 1090 - 1094

Patents

Wasinger V; Leong R, 2017, Diagnostic method for IBD, Patent No. 9797912, https://patentscope.wipo.int/search/en/detail.jsf?docId=US174022017&recNum=1&maxRec=&office=&prevFilter=&sortOption=&queryString=&tab=NationalBiblio
Wasinger V; Leong R, 2017, Diagnostic method for inflammatory bowel disease, U.S., Patent No. US-9797912-B2, http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=US-9797912-B2

Preprints

Manandhar B; Pandzic E; Deshpande N; Chen S-Y; Wasinger V; Kockx M; Glaros E; Ong KL; Thomas SR; Wilkins MR; Whan RM; Cochran BJ; Rye K-A, 2023, ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin, , http://dx.doi.org/10.1101/2023.04.03.535492
Jenkins L; Chang W-J; Buscemi V; Liston M; Nicholas M; Graven-Nielsen T; Hodges P; Wasinger V; Stone L; Dorsey S; McAuley J; Schabrun S, 2021, The Understanding persistent Pain Where it ResiDes study of low back pain cohort profile, , http://dx.doi.org/10.1101/2021.11.24.21266794
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Location

Bioanalytical Mass Spectrometry Facility
Mark Wainwright Analytical Centre
Room 404B, Lv4 Wallace Wurth Building C27
The University of NSW


Contact

+61 (2) 9385 1678
+61 (2) 8214 6831