Ms Sonia Bustamante


Analytical Chemist

Research profile: Click to view



BChem(Hons)(Analytical Chemistry), San Marcos National University, Peru
MChem(Food and Drug Analysis), UNSW Australia

Role & Interests

My work involves the characterisation and/or quantitation of small molecule metabolites in biological systems by GC-MS and LC-MS. Current projects/assays include: Isotope dilution GCMS; Analysis of catecholamines & Kynurenine Pathway metabolites; Nitrates and Nitrites; Glucose; Hormones; Acetylecholine and other quaternary ammonium biological amines; Vitamin D and metabolites. My interest is in targeted metabolomics and the development of quantitative methods. Other duties include training students and other users in the laboratory as well as instrumental techniques.


Book Chapters

Jayasena T; Bustamante S; Poljak A; Sachdev P, 2022, 'Assay of Fatty Acids and Their Role in the Prevention and Treatment of COVID-19', in Multiplex Biomarker Techniques: Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification, Springer US, New York, NY, USA, pp. 213 - 234,
Jayasena T; Bustamante S; Clement J; Welschinger R; Caplan GA; Sachdev PS; Braidy N, 2020, 'Clinical Assessment of the NADome as Biomarkers for Healthy Aging', in Guest PC (ed.), Clinical and Preclinical Models for Maximizing Healthspan Methods and Protocols, Humana, pp. 207 - 216,
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Conference Abstracts

Heng B; Bilgin A; Tan V; Milioli H; Lovejoy D; Bustamante S; Gluch L; Moscato P; Lim C; Guillemin G, 2021, 'Aggressive breast cancer subtype eats tryptophan!', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 17, pp. 15 - 16,
Jayasena T; Poljak A; Bustamante S; Braidy N; Raftery MJ; Sachdev PS, 2017, 'Sirtuin protein and related energy metabolite changes in the Alzheimer brain [Poster Abstract P2-182]', in Alzheimer's and Dementia, Elsevier, London, UK, Vol. 13, pp. P676 - P676, presented at lzheimer's Association International Conference (AAIC) 2017, London, UK, 16 July 2017 - 20 July 2017,
Poljak A; Matayatsuk C; Bustamante S; Sachdev PS; Brodaty H, 2006, 'Quantification of O- and M-tyrosine levels in Alzheimer’s plasma proteins [Abstract Poster PO077]', in Neuropsychiatric Disease and Treatment, Dove Medical Press, Cheshire, UK, Vol. 2, pp. S148 - S148, presented at 6th International Neuropsychiatric Association Congress, Sydney, 10 September 2006 - 14 September 2006

Conference Papers

Adams S; Teo C; McDonald KL; Zinger A; Bustamante S; Lim CK; Sundaram G; Braidy N; Brew BJ; Guillemin GJ, 2014, 'Involvement of the kynurenine pathway in human glioma pathophysiology', in PLoS ONE,

Journal articles

Richani D; Poljak A; Wang B; Mahbub SB; Biazik J; Campbell JM; Habibalahi A; Stocker WA; Marinova MB; Nixon B; Bustamante S; Skerrett-Byrne D; Harrison CA; Goldys E; Gilchrist RB, 2024, 'Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors', American journal of physiology. Endocrinology and metabolism, 326, pp. E366 - E381,
Ong KL; Marklund M; Huang L; Rye KA; Hui N; Pan XF; Rebholz CM; Kim H; Steffen LM; Van Westing AC; Geleijnse JM; Hoogeveen EK; Chen YY; Chien KL; Fretts AM; Lemaitre RN; Imamura F; Forouhi NG; Wareham NJ; Birukov A; Jäger S; Kuxhaus O; Schulze MB; De Mello VD; Tuomilehto J; Uusitupa M; Lindström J; Tintle N; Harris WS; Yamasaki K; Hirakawa Y; Ninomiya T; Tanaka T; Ferrucci L; Bandinelli S; Virtanen JK; Voutilainen A; Jayasena T; Thalamuthu A; Poljak A; Bustamante S; Sachdev PS; Senn MK; Rich SS; Tsai MY; Wood AC; Laakso M; Lankinen M; Yang X; Sun L; Li H; Lin X; Nowak C; Ärnlöv J; Risérus U; Lind L; Le Goff M; Samieri C; Helmer C; Qian F; Micha R; Tin A; Köttgen A; De Boer IH; Siscovick DS; Mozaffarian D; Wu JHY, 2023, 'Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts', BMJ,
Moles E; Howard CB; Huda P; Karsa M; McCalmont H; Kimpton K; Duly A; Chen Y; Huang Y; Tursky ML; Ma D; Bustamante S; Pickford R; Connerty P; Omari S; Jolly CJ; Joshi S; Shen S; Pimanda JE; Dolnikov A; Cheung LC; Kotecha RS; Norris MD; Haber M; de Bock CE; Somers K; Lock RB; Thurecht KJ; Kavallaris M; Moles Meler E, 2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262,
Heng B; Pires AS; Chow S; Krishnamurthy S; Bonnell B; Bustamante S; Guillemin GJ, 2023, 'Stability Studies of Kynurenine Pathway Metabolites in Blood Components Define Optimal Blood Processing Conditions', International Journal of Tryptophan Research, 16,
Field MA; Yadav S; Dudchenko O; Esvaran M; Rosen BD; Skvortsova K; Edwards RJ; Keilwagen J; Cochran BJ; Manandhar B; Bustamante S; Rasmussen JA; Melvin RG; Chernoff B; Omer A; Colaric Z; Chan EKF; Minoche AE; Smith TPL; Gilbert MTP; Bogdanovic O; Zammit RA; Thomas T; Aiden EL; Ballard JWO, 2022, 'The Australian dingo is an early offshoot of modern breed dogs', Science Advances, 8,
Lin Y-L; Wang C-L; Liu K-L; Yeh C-N; Chiang T, 2022, 'Omega-3 Fatty Acids Improve Chronic Kidney Disease-Associated Pruritus and Inflammation', MEDICINA-LITHUANIA, 58,
Bustamante S; Yau Y; Boys V; Chang J; Paramsothy S; Pudipeddi A; Leong RW; Wasinger VC, 2022, 'Tryptophan Metabolism ‘Hub’ Gene Expression Associates with Increased Inflammation and Severe Disease Outcomes in COVID-19 Infection and Inflammatory Bowel Disease', International Journal of Molecular Sciences, 23,
Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD+ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, 30, pp. 1670 - 1681.e7,
Heng B; Bilgin AA; Lovejoy DB; Tan VX; Milioli HH; Gluch L; Bustamante S; Sabaretnam T; Moscato P; Lim CK; Guillemin GJ, 2020, 'Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression', Breast Cancer Research, 22,
Richani D; Lavea CF; Kanakkaparambil R; Riepsamen AH; Bertoldo MJ; Bustamante S; Gilchrist RB, 2019, 'Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism', Scientific Reports, 9,
Bajracharya R; Bustamante S; Ballard JWO, 2019, 'Stearic acid supplementation in high protein to carbohydrate (P:C) Ratio diet improves physiological and mitochondrial functions of Drosophila melanogaster parkin null mutants', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 74, pp. 1564 - 1572,
Wasinger VC; Curnoe D; Bustamante S; Mendoza R; Shoocongdej R; Adler L; Baker A; Chintakanon K; Boel C; Tacon PSC, 2019, 'Analysis of the Preserved Amino Acid Bias in Peptide Profiles of Iron Age Teeth from a Tropical Environment Enable Sexing of Individuals Using Amelogenin MRM', Proteomics, 19, pp. e1800341,
Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, 14,
Aw WC; Towarnicki SG; Melvin RG; Youngson NA; Garvin MR; Hu Y; Nielsen S; Thomas T; Pickford R; Bustamante S; Vila-Sanjurjo A; Smyth GK; Ballard JWO, 2018, 'Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness', PLoS Genetics, 14,
Papa I; Saliba D; Ponzoni M; Bustamante S; Canete PF; Gonzalez-Figueroa P; McNamara HA; Valvo S; Grimbaldeston M; Sweet RA; Vohra H; Cockburn IA; Meyer-Hermann M; Dustin ML; Doglioni C; Vinuesa CG, 2017, 'TFH-derived dopamine accelerates productive synapses in germinal centres', Nature, 547, pp. 318 - 323,
Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC; Chowdhury M, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, 7, pp. 40159,
Lim CK; Bilgin A; Lovejoy DB; Tan V; Bustamante S; Taylor BV; Bessede A; Brew BJ; Guillemin GJ, 2017, 'Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression', Scientific Reports, 7,
Bustamante S; Gilchrist RB; Richani D, 2017, 'A sensitive method for the separation and quantification of low-level adenine nucleotides using porous graphitic carbon-based liquid chromatography and tandem mass spectrometry', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1061-1062, pp. 445 - 451,
Gahreman DE; Boutcher YN; Bustamante S; Boutcher SH, 2016, 'The combined effect of green tea and acute interval sprinting exercise on fat oxidation of trained and untrained males.', J Exerc Nutrition Biochem, 20, pp. 1 - 8,
Sheipouri D; Grant R; Bustamante S; Lovejoy D; Guillemin GJ; Braidy N, 2015, 'Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes', Journal of Cellular Biochemistry, 116, pp. 903 - 922,
Yau YY; Leong RWL; Shin S; Bustamante S; Pickford R; Hejazi L; Campbell B; Wasinger VC, 2014, 'Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases', Discovery Medicine, 18, pp. 113 - 124
Adams S; Teo C; McDonald KL; Zinger A; Bustamante S; Lim CK; Sundaram G; Braidy N; Brew BJ; Guillemin GJ, 2014, 'Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology', PLOS ONE, 9,
Purves-Tyson TD; Handelsman D; Double KL; Bustamante S; owens SJ; Shannon Weickert C, 2012, 'Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra', BMC Neuroscience, 13, pp. 95,
Yau Y; Shin SS; Bustamante S; Pickford R; Leong RW; Wasinger VC, 2011, 'Tryptophan Metabolome Signature Differences in Inflammatory Bowel Diseases', Gastroenterology, 140, pp. S - 840,
Phillips PA; Yang L; Shulkes A; Vonlaufen A; Poljak A; Bustamante S; Warren A; Xu ; Guilhaus M; Pirola R; Apte MV; Wilson JS, 2010, 'Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 17397 - 17402,
Bustamante S; Pickford R; Shin S; Luber R; Campbell B; Redmond D; Yau Y; Leong RWL; Wasinger V, 2010, 'Metabolomics in inflammatory bowel disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 25, pp. A83 - A83,
Phillips PA; Yang L; Poljak A; Bustamante S; Shulkes A; Vonlaufen A; Xu Z; Guilhaus M; Pirola R; Apte M; Wilson J, 2009, 'Pancreatic Stellate Cells Stimulate Acinar Enzyme Secretion Via the Production of Acetylcholine', PANCREAS, 38, pp. 1038 - 1039,
Phillips PA; Yang L; Poljak A; Bustamante S; Shulkes A; Vonlaufen A; Xu Z; Pirola R; Apte M; Wilson J, 2009, 'Pancreatic stellate cells synthesise and secrete acetylcholine: a potential role in enzyme secretion', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24, pp. A335 - A335,
Matayatsuk C; Poljak A; Bustamante S; Smythe GA; Kalpravidh R; Sirankapracha P; Fucharoen S; Wilairat P, 2007, 'Quantitative determination of ortho- and meta-tyrosine as biomarkers of protein oxidative damage in beta-thalassemia', Redox Report, 12, pp. 219 - 228
Clark CJ; Mackay G; Smythe GA; Stone T; Phillips R; Bustamante S, 2005, 'Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition', Infection and Immunity, 73, pp. 5249 - 5251
Smythe G; Poljak A; Bustamante S; Braga O; Maxwell A; Grant R; Perminder S, 2003, 'GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue', Developments in Tryptophan and Serotonin Metabolism, 527, pp. 705 - 712

Working Papers

Yadav S; Dudchenko O; Esvaran M; Rosen B; Field M; Skvortsova K; Gopalakrishnan S; Keilwagen J; Cochran B; Manandhar B; Bucknall M; Bustamante S; Rasmussen J; Melvin R; Omer A; Colaric Z; Chan E; Minoche A; Smith T; Gilbert T; Bogdanovic O; Zammit R; Thomas T; Aiden E; Ballard B; Edwards R, 2020, Desert Dingo (Canis lupus dingo) genome provides insights into their role in the Australian ecosystem, Cold Spring Harbor, http://dx.doi.org10.1101/2020.11.15.384057,
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