Head, Preclinical Imaging and Biospecimen Research Facilities; Program Lead – Health Research Platforms; National Imaging Facility Node Director
Facility:
Category: Academic Staff
Research profile: Click to view
Biography
Dr Carl Power heads multiple facilities in the Mark Wainwright Analytical Centre including the Biological Resources Imaging Laboratory, the UNSW Flow Cytometry Facility, Biospecimen Services and Cold Storage Services. He is also the Program Lead for UNSW Health Research Platforms, and a Node Director for the UNSW Node of the NCRIS-supported project, the Australian National Imaging Facility.
Research Interests:
As Head of BRIL, Dr Power has diverse interests in preclinical imaging techniques including MRI, PET, CT, Optical Imaging and Ultrasound and their application to research. Dr Power's research in the area of cancer biology in general, and specifically prostate cancer biology, is focused on use of animal models to identify mechanisms of prostate cancer metastasis to bone, immune responses to prostate cancer and its bone metastases and preclinical assessment of treatments to prevent bone metastasis.
Broad Research Areas:
Preclinical Imaging, Cancer, Immunology, Cell Biology
Qualifications:
Dr Power completed a PhD in the Department of Microbiology and Immunology at the University of Saskatchewan, Canada, before immigrating to Australia in 2000. He also holds a MSc in Immunology from the Atlantic Veterinary College and a BSc from the University of Prince Edward Island.
Society Memberships & Professional Activities: Member of the World Molecular Imaging Society
Specific Research Keywords:
Preclinical Imaging, Biospecimens, Biobanking, Flow Cytometry, Prostate Cancer, Bone Metastasis, Immunology,
Publications
Book Chapters
, 2010, 'Biomarkers for radiosensitivity and radiosensitivity targets in prostate cancer', in Nguyen SD (ed.), Tumour Suppressors, Nova Science Publishers, USA, pp. 189 - 228
Conference Abstracts
, 2005, 'Regulatory T cells and the maintenance of tolerance', in TISSUE ANTIGENS, BLACKWELL PUBLISHING, AUSTRALIA, Melbourne, Vol. 66, pp. 412 - 412, presented at 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, AUSTRALIA, Melbourne, 29 November 2005 - 02 December 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233542700194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
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Conference Papers
, 2015, 'Evaluation of F-18-TSPO radiotracers in a prostate tumour model using PET', in JOURNAL OF NUCLEAR MEDICINE, SOC NUCLEAR MEDICINE INC, MD, Baltimore, presented at Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging, MD, Baltimore, 06 June 2015 - 10 June 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358738801206&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2014, 'IMAGE-QUALITY ASSESSMENT OF SEVERAL POSITRON EMITTERS FOR PRECLINICAL IMAGING', in INTERNAL MEDICINE JOURNAL, WILEY-BLACKWELL, pp. 33 - 33, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334282000098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2010, 'Circulating and tumour-infiltrating CD4+IL-17+ T-cells in mice bearing orthotopic and heterotopic prostate tumours', in Proceedings of the American Association for Cancer Research, American Association Cancer Research, Philadelphia, PA, USA, pp. 1162 - 1162, presented at AACR 101st Annual Meeting, Walter E.Washington Convention Centre, Washington DC, 17 April 2010 - 21 April 2010
, 2009, 'Combined Docetaxel and Zoledronic Acid Treatment for Bone Metastatic Murine Prostate Cancer.', in Cancer & Bone Society, VIIIth International Meeting on Cancer Induced Bone Disease, Online, presented at VIIIth International Meeting on Cancer Induced Bone Disease, Sydney, 25 March 2009 - 26 March 2009
, 2006, 'Control of DU 145 and LNCaP-LN3 prostate cancer spheroid growth using 213Bi-labeled multiple targeted alpha radioimmunoconjugates', in Annals of Oncology, Oxford Univ Press, Oxford, England, presented at Symposium on targeted anticancer therapies, Amsterdam, 16 March 2006 - 18 March 2006, http://dx.doi.org/10.1093/annonc/mdl921
, 2005, 'IL-18 expression inhibits growth of RM1 murine prostate carcinomas', in Tissue Antigens, Blackwell Munksgaard, Copenhagen, Denmark, pp. 568 - 568, presented at Genetics and The Immune Response’ Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, http://dx.doi.org/10.1111/j.1399-0039.2005.00523.x
, 2005, 'Inhibition of tumorigenicity of invasive human bladder cancer cells by a non-tumorigenic subline from the same xenograft: Identification of differentially expressed genes.', in Cancer epidemiology biomarkers and prevention, American Association Cancer Research, Philadelphia, PA, USA, pp. 2742S - 2743S, presented at 4th Annual Conference on Frontiers in Cancer Prevention Research, Washington, 30 October 2005 - 02 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233351200253&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Conference Presentations
, 2017, 'DECLINED PRESENTATION MESENCHYMAL STEM CELL-LIKE CELL MEDIATED HEMATOPOIETIC STEM CELL GENERATION FROM NON-HEMOGENIC ENDOTHELIAL CELLS', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900274&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Journal articles
, 2022, 'Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque', Redox Biology, 58, http://dx.doi.org/10.1016/j.redox.2022.102532
, 2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3
, 2021, 'Synthesis and pharmacological evaluation of [18F]PBR316: a novel PET ligand targeting the translocator protein 18 kDa (TSPO) with low binding sensitivity to human single nucleotide polymorphism rs6971', RSC Medicinal Chemistry, 12, pp. 1207 - 1221, http://dx.doi.org/10.1039/d1md00035g
, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, 7, pp. eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
, 2021, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Science Advances, pp. 2020.06.04.130872 - 2020.06.04.130872, http://dx.doi.org/10.1126/sciadv.abd1929
, 2021, 'Moving with the Times: The Health Science Alliance (HSA) Biobank, Pathway to Sustainability', Biomarker Insights, 16, pp. 1 - 10, http://dx.doi.org/10.1177/11772719211005745
, 2021, 'Mesoderm-Derived PDGFRA+Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', , http://dx.doi.org/10.1101/2021.08.08.455592
, 2018, 'A hypothesis for the existence of two types of tuberculosis, reflecting two distinct types of immune failure to control the pathogen, based upon prevalence of mycobacterium-specific IgG subclasses', Scandinavian Journal of Immunology, 87, http://dx.doi.org/10.1111/sji.12665
, 2018, 'Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque', European Heart Journal, 39, pp. 3301 - 3310, http://dx.doi.org/10.1093/eurheartj/ehy419
, 2017, 'DECLINED PRESENTATION CHARACTERISATION OF STROMAL CELL POPULATIONS IN THE FOETAL LIVER AND THEIR CONTRIBUTIONS TO EMBRYONIC HAEMATOPOIETIC AND VASCULAR DEVELOPMENT', EXPERIMENTAL HEMATOLOGY, 53, pp. S118 - S118, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900273&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2015, 'Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease', Journal of Clinical Investigation, 125, pp. 3627 - 3641, http://dx.doi.org/10.1172/JCI76031
, 2015, 'Microscopic diffusion properties of fixed breast tissue: Preliminary findings', Magnetic Resonance in Medicine, 74, pp. 1733 - 1739, http://dx.doi.org/10.1002/mrm.25555
, 2014, 'From Bench to Bedside: Immunotherapy for Prostate Cancer', BioMed Research International, 2014, http://dx.doi.org/10.1155/2014/981434
, 2014, 'A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone', DMM Disease Models and Mechanisms, 7, pp. 299 - 309, http://dx.doi.org/10.1242/dmm.014076
, 2014, 'DISTINCTIVE WATER DIFFUSION PROPERTIES OF EPITHELIA MAY BE THE KEY TO BETTER CANCER IMAGING TECHNIQUES', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 10, pp. 24 - 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2013, 'The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo', Birth Defects Research Part B - Developmental and Reproductive Toxicology, 98, pp. 144 - 153, http://dx.doi.org/10.1002/bdrb.21050
, 2013, 'Humanised xenograft models of bone metastasis revisited: Novel insights into species-specific mechanisms of cancer cell osteotropism', Cancer and Metastasis Reviews, 32, pp. 129 - 145, http://dx.doi.org/10.1007/s10555-013-9437-5
, 2013, 'Combination Therapy with the Histone Deacetylase Inhibitor LBH589 and Radiation Is an Effective Regimen for Prostate Cancer Cells', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0074253
, 2012, 'The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo', Molecular and Cellular Biology, 32, pp. 3281 - 3292, http://dx.doi.org/10.1128/MCB.00173-12
, 2012, 'CD44 is a biomarker associated with human prostate cancer radiation sensitivity', Clinical and Experimental Metastasis, 29, pp. 1 - 9, http://dx.doi.org/10.1007/s10585-011-9423-7
, 2012, 'In Vitro and In Vivo Prostate Cancer Metastasis and Chemoresistance Can Be Modulated by Expression of either CD44 or CD147', PLoS One, 7, pp. 1 - 14, http://dx.doi.org/10.1371/journal.pone.0040716
, 2011, 'IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms', PLoS One, 6, pp. e24241, http://dx.doi.org/10.1371/journal.pone.0024241
, 2011, 'Zoledronic acid preserves bone structure and increases survival but does not limit tumour incidence in a prostate cancer bone metastasis model', PLoS One, 6, pp. 1 - 8, http://dx.doi.org/10.1371/journal.pone.0019389
, 2011, 'Monoclonal antibody targeting MUC1 and increasing sensitivity to docetaxel as a novel strategy in treating human epithelial ovarian cancer', Cancer Letters, 300, pp. 122 - 133, http://dx.doi.org/10.1016/j.canlet.2010.09.013
, 2010, 'CD147/EMMPRIN and CD44 are Potential Therapeutic Targets for Metastatic Prostate Cancer', Current Cancer Drug Targets, 10, pp. 287 - 306
, 2010, 'Development of Th1 Imprints to rBCG Expressing a Foreign Protein: Implications for Vaccination against HIV-1 and Diverse Influenza Strains', Journal of Biomedicine and Biotechnology, 2010, pp. 1 - 6, http://dx.doi.org/10.1155/2010/591348
, 2010, 'Immunization of newborn and adult mice with low numbers of BCG leads to Th1 responses, Th1 imprints and enhanced protection upon BCG challenge', Immunotherapy, 2, pp. 25 - 35
, 2009, 'A novel model of bone-metastatic prostate cancer in immunocompetent mice', Prostate, 69, pp. 1613 - 1623
, 2009, 'Inhibition of Micrometastatic Prostate Cancer Cell Spread in Animal Models By (213)Bilabeled Multiple Targeted alpha Radioimmunoconjugates', Clinical Cancer Research, 15, pp. 865 - 875, http://dx.doi.org/10.1158/1078-0432.CCR-08-1203
, 2006, 'Control of prostate cancer spheroid growth using 213Bi-labeled multiple targeted alpha radioimmunoconjugates.', Prostate, 66, pp. 1753 - 1767
, 2000, 'Factors that influence T helper cell response to infection', Current Opinion in Infectious Diseases, 13, pp. 209 - 213
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Location
Biological Resources Imaging Lab &
Biospecimen Services
Mark Wainwright Analytical Centre
Room 423, Level 4, Lowy Cancer Research Centre
University of New South Wales
Sydney, NSW 2052, Australia
Biospecimen Services
Mark Wainwright Analytical Centre
Room 423, Level 4, Lowy Cancer Research Centre
University of New South Wales
Sydney, NSW 2052, Australia
